Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 847695..848355 Replicon chromosome
Accession NZ_CP026977
Organism Pectobacterium parmentieri strain IFB5408

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B3EZX7
Locus tag C5E17_RS04025 Protein ID WP_012822581.1
Coordinates 847942..848355 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3I0G9
Locus tag C5E17_RS04020 Protein ID WP_012822580.1
Coordinates 847695..847961 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5E17_RS04000 843689..844693 - 1005 WP_012822576.1 substrate-binding domain-containing protein -
C5E17_RS04005 844747..845355 - 609 WP_014698756.1 HD domain-containing protein -
C5E17_RS04010 845764..846411 + 648 WP_012822578.1 hemolysin III family protein -
C5E17_RS04015 846466..847467 - 1002 WP_012822579.1 tRNA-modifying protein YgfZ -
C5E17_RS04020 847695..847961 + 267 WP_012822580.1 FAD assembly factor SdhE Antitoxin
C5E17_RS04025 847942..848355 + 414 WP_012822581.1 protein YgfX Toxin
C5E17_RS04030 848581..849516 + 936 WP_012822582.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
C5E17_RS04035 849603..849926 - 324 WP_012822583.1 hypothetical protein -
C5E17_RS04040 849955..850473 - 519 WP_033070904.1 flavodoxin FldB -
C5E17_RS04045 850801..851817 + 1017 WP_012822585.1 methionine ABC transporter ATP-binding protein -
C5E17_RS04050 851810..852478 + 669 WP_012822586.1 ABC transporter permease -
C5E17_RS04055 852496..853314 + 819 WP_033071942.1 MetQ/NlpA family ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16259.20 Da        Isoelectric Point: 10.7923

>T96932 WP_012822581.1 NZ_CP026977:847942-848355 [Pectobacterium parmentieri]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWRIVKRPWLLKNGVLLALQSANGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T96932 NZ_CP026977:847942-848355 [Pectobacterium parmentieri]
GTGGCCCAGTGGCAATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGTCTATTAGTGTT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTGTGGCTGTGTTTGGTCACAATGGTGATGTTTGGTTTCA
TCCGTAGCCAAAGGAATATCAAATCGCGGCAAGGGTGCATCACGCTGCTTAGCGAAACGACCTTGAACTGGCGGCAGCAG
GAGTGGCGGATTGTCAAACGACCGTGGTTGCTGAAAAATGGTGTGTTATTGGCATTGCAATCGGCTAATGGGAAAGACAA
GCAACAACTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCATCTGCGCCAGCTTCTTTTGCAGCAAAAAC
ACTGGGCGAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.99 Da        Isoelectric Point: 5.1392

>AT96932 WP_012822580.1 NZ_CP026977:847695-847961 [Pectobacterium parmentieri]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDIDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT96932 NZ_CP026977:847695-847961 [Pectobacterium parmentieri]
ATGGAAATCGATAACAAATCACGTATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTGGATATCGCCATCATGCCGTT
TTTTGAGCATGACTATGACACATTAAACGATATAGATAAGCGCACGTTTGTACGCCTGCTACAAAGCGACGATCCCGATT
TATTCAACTGGCTAATGAACCACGGTGAGCCAGAAGACGGAGAGCTAAAACGCATGATTTCCCTTATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3EZX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I0G9

References