96930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 514610..515646 Replicon chromosome
Accession NZ_CP026977
Organism Pectobacterium parmentieri strain IFB5408

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A8B3FNB9
Locus tag C5E17_RS02480 Protein ID WP_033070784.1
Coordinates 515071..515646 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A8B3FHU5
Locus tag C5E17_RS02475 Protein ID WP_033070783.1
Coordinates 514610..515071 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5E17_RS02445 511217..511753 - 537 WP_033070780.1 ash family protein -
C5E17_RS02450 511750..511950 - 201 WP_014698606.1 AlpA family transcriptional regulator -
C5E17_RS02455 511953..512831 - 879 WP_033070781.1 integrase domain-containing protein -
C5E17_RS23590 513378..513629 - 252 WP_127087855.1 hypothetical protein -
C5E17_RS02460 513844..513918 + 75 Protein_468 type II toxin-antitoxin system RelE/ParE family toxin -
C5E17_RS02470 514087..514305 - 219 Protein_469 hypothetical protein -
C5E17_RS02475 514610..515071 + 462 WP_033070783.1 helix-turn-helix domain-containing protein Antitoxin
C5E17_RS02480 515071..515646 + 576 WP_033070784.1 PIN domain-containing protein Toxin
C5E17_RS02485 515815..516936 - 1122 WP_033070785.1 XRE family transcriptional regulator -
C5E17_RS02490 516923..517747 - 825 WP_127087856.1 hypothetical protein -
C5E17_RS02495 517809..518021 - 213 WP_082218588.1 DUF1133 family protein -
C5E17_RS02500 518563..519825 + 1263 WP_033070786.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 505530..522536 17006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

SinI-like, DNA-binding domain

(84-131)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21771.27 Da        Isoelectric Point: 4.8050

>T96930 WP_033070784.1 NZ_CP026977:515071-515646 [Pectobacterium parmentieri]
MNHSPYPVVLDACVIYPNMLRDLLMEVGKSGLYQPKWTATIHDEWQRNLVENVPDLTREKLKRVEDLMNKALPDALVTGF
ENLMEGVSLPDLDDRHVVAAAIRSDSEVIVTFNLKDFPKESLAEFDIEAIHPDEFIADLLDLNQALVLQAVQRQRARLKN
PKKSVDEYFDILLKLGLPMTVKAITAYKLMI

Download         Length: 576 bp

>T96930 NZ_CP026977:515071-515646 [Pectobacterium parmentieri]
ATGAATCATTCGCCTTACCCAGTCGTACTTGATGCCTGTGTCATTTATCCCAACATGCTCCGCGATCTGCTTATGGAGGT
TGGGAAATCGGGTCTGTATCAACCTAAATGGACGGCCACCATTCATGATGAATGGCAAAGAAATTTGGTTGAAAACGTAC
CGGATTTAACGCGTGAAAAATTGAAGCGCGTAGAGGATCTGATGAACAAAGCCCTACCTGATGCTCTTGTAACGGGCTTT
GAAAATCTTATGGAAGGGGTTTCACTCCCAGATCTTGACGATCGCCATGTTGTAGCTGCAGCGATAAGATCCGATTCAGA
GGTGATCGTAACCTTCAATCTTAAAGACTTTCCAAAGGAGAGCCTGGCTGAGTTTGATATTGAAGCAATTCATCCTGATG
AGTTTATCGCTGATTTGCTGGATTTAAATCAAGCCTTAGTTTTACAGGCTGTCCAAAGGCAGCGAGCCCGGCTAAAGAAC
CCCAAAAAATCAGTAGATGAATATTTCGACATACTACTGAAACTAGGCTTGCCGATGACGGTTAAGGCTATAACTGCTTA
TAAATTAATGATTTAG

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17321.80 Da        Isoelectric Point: 6.1440

>AT96930 WP_033070783.1 NZ_CP026977:514610-515071 [Pectobacterium parmentieri]
MTSSILDNVSLPAQKEIEVALRGQRELATFLTTKFETQKISIHDANDEKHQIELPTSALRLLMNILGELAEGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEEGKLPHHKTGRHRRVLFADLMRYKAQRETESNEAMQELVDLSQELGFY

Download         Length: 462 bp

>AT96930 NZ_CP026977:514610-515071 [Pectobacterium parmentieri]
ATGACTAGCTCAATTCTGGACAATGTAAGCCTTCCGGCTCAGAAGGAAATTGAGGTTGCGTTACGTGGACAAAGAGAACT
GGCAACATTTCTCACCACAAAGTTCGAAACGCAAAAAATATCGATTCACGATGCAAACGACGAAAAACACCAGATCGAAT
TGCCAACCTCAGCACTGAGATTGCTAATGAACATCTTGGGTGAACTCGCTGAAGGGAACGCGGTTCAAGTTGTCCCTGTG
CACGCTGAATTAACTACACAGGAGGCCGCCAATATTCTGAATGTTTCACGCCCTCACATGGTGAAGCTTTTAGAAGAAGG
AAAGCTTCCACATCATAAAACAGGCCGTCATCGCCGCGTTCTTTTTGCTGATTTGATGCGCTATAAAGCTCAGCGTGAAA
CTGAGAGCAATGAAGCAATGCAAGAACTGGTTGATTTGAGCCAGGAACTTGGTTTTTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3FNB9

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3FHU5

References