Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 2579651..2580294 | Replicon | chromosome |
Accession | NZ_CP026975 | ||
Organism | Enterobacter cloacae complex sp. strain FDAARGOS_77 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A443XCP1 |
Locus tag | MC67_RS13115 | Protein ID | WP_045337409.1 |
Coordinates | 2579651..2580067 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q84A07 |
Locus tag | MC67_RS13120 | Protein ID | WP_001261276.1 |
Coordinates | 2580064..2580294 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MC67_RS13100 | 2575517..2576860 | + | 1344 | WP_032192047.1 | APC family permease | - |
MC67_RS13105 | 2578182..2579282 | + | 1101 | WP_032192045.1 | NADH:flavin oxidoreductase/NADH oxidase | - |
MC67_RS13110 | 2579370..2579615 | - | 246 | WP_045337411.1 | hypothetical protein | - |
MC67_RS13115 | 2579651..2580067 | - | 417 | WP_045337409.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MC67_RS13120 | 2580064..2580294 | - | 231 | WP_001261276.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
MC67_RS24650 | 2580849..2581193 | - | 345 | WP_047747546.1 | hypothetical protein | - |
MC67_RS13130 | 2581273..2581970 | - | 698 | Protein_2517 | IS1 family transposase | - |
MC67_RS24490 | 2582028..2582102 | + | 75 | Protein_2518 | type II toxin-antitoxin system RelE/ParE family toxin | - |
MC67_RS13140 | 2582281..2582715 | - | 435 | WP_047634294.1 | hypothetical protein | - |
MC67_RS13145 | 2582931..2584331 | - | 1401 | WP_002436614.1 | copper resistance membrane spanning protein PcoS | - |
MC67_RS13150 | 2584328..2585008 | - | 681 | WP_001188930.1 | copper response regulator transcription factor PcoR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2549596..2620579 | 70983 | |
- | flank | IS/Tn | - | - | 2581273..2581566 | 293 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15066.53 Da Isoelectric Point: 8.5403
>T96916 WP_045337409.1 NZ_CP026975:c2580067-2579651 [Enterobacter cloacae complex sp.]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVK
Download Length: 417 bp
>T96916 NZ_CP026975:c2580067-2579651 [Enterobacter cloacae complex sp.]
ATGAAGAAAACCTGGATGCTCGATACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTACTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAATAATACACGGGAGTTTGAGCGGGTGCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA
ATGAAGAAAACCTGGATGCTCGATACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTACTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAATAATACACGGGAGTTTGAGCGGGTGCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT96916 WP_001261276.1 NZ_CP026975:c2580294-2580064 [Enterobacter cloacae complex sp.]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT96916 NZ_CP026975:c2580294-2580064 [Enterobacter cloacae complex sp.]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A443XCP1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A387K023 |