Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2579651..2580294 Replicon chromosome
Accession NZ_CP026975
Organism Enterobacter cloacae complex sp. strain FDAARGOS_77

Toxin (Protein)


Gene name vagD Uniprot ID A0A443XCP1
Locus tag MC67_RS13115 Protein ID WP_045337409.1
Coordinates 2579651..2580067 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag MC67_RS13120 Protein ID WP_001261276.1
Coordinates 2580064..2580294 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC67_RS13100 2575517..2576860 + 1344 WP_032192047.1 APC family permease -
MC67_RS13105 2578182..2579282 + 1101 WP_032192045.1 NADH:flavin oxidoreductase/NADH oxidase -
MC67_RS13110 2579370..2579615 - 246 WP_045337411.1 hypothetical protein -
MC67_RS13115 2579651..2580067 - 417 WP_045337409.1 type II toxin-antitoxin system VapC family toxin Toxin
MC67_RS13120 2580064..2580294 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MC67_RS24650 2580849..2581193 - 345 WP_047747546.1 hypothetical protein -
MC67_RS13130 2581273..2581970 - 698 Protein_2517 IS1 family transposase -
MC67_RS24490 2582028..2582102 + 75 Protein_2518 type II toxin-antitoxin system RelE/ParE family toxin -
MC67_RS13140 2582281..2582715 - 435 WP_047634294.1 hypothetical protein -
MC67_RS13145 2582931..2584331 - 1401 WP_002436614.1 copper resistance membrane spanning protein PcoS -
MC67_RS13150 2584328..2585008 - 681 WP_001188930.1 copper response regulator transcription factor PcoR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2549596..2620579 70983
- flank IS/Tn - - 2581273..2581566 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-129)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 15066.53 Da        Isoelectric Point: 8.5403

>T96916 WP_045337409.1 NZ_CP026975:c2580067-2579651 [Enterobacter cloacae complex sp.]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

>T96916 NZ_CP026975:c2580067-2579651 [Enterobacter cloacae complex sp.]
ATGAAGAAAACCTGGATGCTCGATACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTACTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAATAATACACGGGAGTTTGAGCGGGTGCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT96916 WP_001261276.1 NZ_CP026975:c2580294-2580064 [Enterobacter cloacae complex sp.]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT96916 NZ_CP026975:c2580294-2580064 [Enterobacter cloacae complex sp.]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A443XCP1


Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References