Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2518190..2518716 Replicon chromosome
Accession NZ_CP026975
Organism Enterobacter cloacae complex sp. strain FDAARGOS_77

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag MC67_RS12755 Protein ID WP_000323025.1
Coordinates 2518429..2518716 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag MC67_RS12750 Protein ID WP_004196370.1
Coordinates 2518190..2518429 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC67_RS12720 2513527..2513719 - 193 Protein_2436 MFS transporter -
MC67_RS12725 2513749..2514726 + 978 WP_004196334.1 chromate resistance protein -
MC67_RS12730 2514683..2516059 + 1377 WP_004196363.1 chromate efflux transporter -
MC67_RS12735 2516090..2516779 - 690 WP_004196322.1 hypothetical protein -
MC67_RS12740 2516793..2517530 - 738 WP_008460272.1 HupE/UreJ family protein -
MC67_RS12745 2517574..2517939 - 366 WP_009651956.1 hypothetical protein -
MC67_RS12750 2518190..2518429 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
MC67_RS12755 2518429..2518716 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
MC67_RS12760 2518788..2518946 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
MC67_RS12765 2519825..2520139 + 315 WP_023338051.1 hypothetical protein -
MC67_RS12770 2520199..2520660 + 462 WP_048974901.1 hypothetical protein -
MC67_RS12775 2520750..2520950 + 201 WP_031494497.1 hypothetical protein -
MC67_RS12780 2520991..2521782 + 792 WP_032663722.1 N-6 DNA methylase -
MC67_RS12785 2521825..2522160 + 336 WP_023345479.1 hypothetical protein -
MC67_RS12790 2522850..2523143 + 294 WP_032663725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T96915 WP_000323025.1 NZ_CP026975:2518429-2518716 [Enterobacter cloacae complex sp.]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T96915 NZ_CP026975:2518429-2518716 [Enterobacter cloacae complex sp.]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT96915 WP_004196370.1 NZ_CP026975:2518190-2518429 [Enterobacter cloacae complex sp.]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT96915 NZ_CP026975:2518190-2518429 [Enterobacter cloacae complex sp.]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References