Detailed information of TA system TA096913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 4820732..4822346
• Replicon: chromosome
• Accession: NZ_CP026973
• Organism: Achromobacter insolitus strain FDAARGOS_88

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MC81_RS22395
• Protein ID: WP_042795665.1
• Coordinates: 4820732..4822084 (-)
• Length: 451 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A6S7FIA7
• Locus tag: MC81_RS22400
• Protein ID: WP_042795666.1
• Coordinates: 4822089..4822346 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC81_RS22375	4816611..4817825	-	1215	WP_088607648.1	ABC transporter substrate-binding protein	-
MC81_RS22380	4818052..4818723	+	672	WP_063639549.1	Crp/Fnr family transcriptional regulator	-
MC81_RS22385	4818720..4819841	-	1122	WP_042797453.1	MFS transporter	-
MC81_RS22390	4819934..4820701	+	768	WP_042795664.1	helix-turn-helix transcriptional regulator	-
MC81_RS22395	4820732..4822084	-	1353	WP_042795665.1	type II toxin-antitoxin system HipA family toxin	Toxin
MC81_RS22400	4822089..4822346	-	258	WP_042795666.1	helix-turn-helix domain-containing protein	Antitoxin
MC81_RS22405	4822535..4823755	-	1221	WP_042795667.1	polysaccharide lyase family 1 protein	-
MC81_RS22410	4823768..4825672	-	1905	WP_042795669.1	Vi polysaccharide transport protein VexE	-
MC81_RS22415	4825665..4826696	-	1032	WP_042797454.1	sugar ABC transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-66)

Sequences

Toxin

Protein

• Length: 451 a.a.
• Molecular weight: 49380.55 Da
• Isoelectric Point: 7.4842

>T96913 WP_042795665.1 NZ_CP026973:c4822084-4820732 [Achromobacter insolitus]
MGRRSHTQALGLWMNGAYVGEWSNRPHAGEVLQYDKDWVASAPGRPLSLSLPFTPGNGPHRGNVVRAYFENLLPDSKEIR
ERVARRFRAGSTDAFALLAEIGRDCAGALQILPAGIAPADVASVQASPLNDAQVAQLLRSVLAPAPLGGLAIAEDDFRIS
IAGAQEKTALLRMDGQWCLPQGATPTTHILKLPLGLVGNMKFDLSESVENEWLCSEILAAYGMPVARAEVLSFEDMKVLA
VERFDRRWWDGEDGKRSLVRLPQEDMCQATGTPPHLKYEADGGPGIDRIMGLLETSRRSEHDRRTFFQAQVLFWMLCATD
GHAKNFSLFLRPGGAYELTPLYDVLSAYPILGEGPGKLSPVRAKMAMAVRSKNPHWRMRDIQRRHWLTVGARHGVVTPDG
QGVQFVVDDLIARTPEAMRAVRARLPQGFPQVLADSILDGLQAAADRLAA

Nucleotide

• Length: 1353 bp

>T96913 NZ_CP026973:c4822084-4820732 [Achromobacter insolitus]
ATGGGGCGACGTTCACACACGCAGGCCCTGGGCCTATGGATGAATGGCGCCTATGTCGGAGAGTGGAGCAATCGACCCCA
CGCCGGCGAGGTCCTGCAGTACGACAAGGACTGGGTCGCCTCCGCGCCGGGCAGGCCATTGTCGCTGTCCCTGCCCTTCA
CGCCGGGCAATGGCCCGCATCGCGGCAACGTCGTCCGCGCATACTTCGAAAATCTGCTGCCTGACAGCAAGGAAATCCGC
GAACGGGTTGCGCGCCGGTTCCGGGCAGGCTCGACCGACGCGTTCGCCTTGCTTGCCGAGATCGGTCGCGATTGCGCGGG
CGCCTTGCAGATCCTGCCTGCGGGAATAGCGCCTGCAGACGTGGCGTCGGTGCAAGCCTCGCCCTTGAACGATGCCCAGG
TTGCGCAGCTGTTGCGCAGTGTTTTGGCGCCGGCGCCTCTCGGCGGCCTGGCCATCGCTGAGGATGATTTCCGGATTTCC
ATTGCAGGTGCGCAAGAGAAGACCGCCTTGCTGCGGATGGACGGCCAATGGTGCTTGCCCCAAGGCGCCACGCCGACGAC
TCACATCCTGAAGTTGCCATTGGGGCTGGTCGGCAATATGAAGTTCGACCTGAGCGAATCGGTGGAAAACGAATGGCTCT
GCTCGGAGATCTTGGCTGCCTACGGCATGCCCGTGGCGCGCGCGGAAGTACTGAGCTTCGAAGACATGAAGGTGCTCGCC
GTCGAACGTTTCGACCGCCGCTGGTGGGACGGCGAAGACGGAAAGCGCAGTCTAGTCCGCCTGCCCCAGGAAGACATGTG
CCAGGCCACCGGCACCCCGCCACACCTGAAGTACGAGGCGGACGGCGGGCCCGGCATCGACCGCATCATGGGCCTGCTCG
AAACTTCGCGTCGCTCAGAGCATGACCGGCGGACGTTCTTCCAGGCGCAGGTTCTGTTCTGGATGCTGTGCGCGACGGAC
GGCCACGCGAAGAACTTCAGCCTGTTCCTGCGGCCGGGCGGGGCCTACGAACTTACACCGCTATACGACGTGCTGTCCGC
CTATCCGATCCTGGGCGAGGGACCAGGCAAGCTGTCGCCCGTTAGAGCGAAGATGGCGATGGCCGTGCGTTCGAAGAACC
CGCATTGGCGCATGCGCGATATCCAGCGGCGCCACTGGTTGACGGTGGGCGCGCGACATGGCGTCGTGACGCCGGACGGC
CAGGGAGTCCAATTCGTCGTTGACGATTTGATCGCGCGTACGCCAGAGGCCATGCGTGCGGTCCGCGCCAGATTGCCACA
AGGATTTCCGCAGGTGCTGGCGGACAGCATCCTGGACGGCTTGCAGGCCGCGGCGGACAGGCTCGCCGCGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9220.58 Da
• Isoelectric Point: 8.9814

>AT96913 WP_042795666.1 NZ_CP026973:c4822346-4822089 [Achromobacter insolitus]
MDFTVRTATQLPALLQGFRKEAGLTQAATALRLGVTQQTLSALERNADKVSADRLLQLLSILGVEMVLRRQGAQPGPETT
SEPSW

Nucleotide

• Length: 258 bp

>AT96913 NZ_CP026973:c4822346-4822089 [Achromobacter insolitus]
ATGGATTTCACCGTACGCACCGCGACACAATTGCCGGCCCTGCTCCAGGGGTTCCGCAAAGAGGCCGGCTTGACCCAGGC
GGCCACGGCCTTGCGCCTTGGGGTCACACAACAGACCTTGTCCGCCCTGGAGCGCAATGCCGACAAGGTCAGCGCAGACC
GGCTGCTGCAGCTGTTGAGCATCCTGGGAGTCGAAATGGTCTTGCGCCGGCAAGGGGCGCAGCCGGGACCCGAAACAACA
TCCGAACCCAGCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6S7FIA7