Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2395857..2396380 Replicon chromosome
Accession NZ_CP026968
Organism Staphylococcus aureus strain FDAARGOS_1

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag RK60_RS12735 Protein ID WP_000074049.1
Coordinates 2395857..2396123 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag RK60_RS12740 Protein ID WP_000587616.1
Coordinates 2396123..2396380 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK60_RS12715 2391164..2392351 - 1188 WP_000026189.1 MFS transporter -
RK60_RS12720 2392747..2393523 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
RK60_RS12725 2393516..2394178 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
RK60_RS12730 2394426..2395502 - 1077 WP_001076673.1 M42 family metallopeptidase -
RK60_RS12735 2395857..2396123 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
RK60_RS12740 2396123..2396380 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK60_RS12750 2396739..2397194 + 456 WP_000732076.1 DUF1307 domain-containing protein -
RK60_RS12755 2397362..2398939 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
RK60_RS12760 2399134..2399883 + 750 WP_000072462.1 CPBP family intramembrane metalloprotease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T96912 WP_000074049.1 NZ_CP026968:c2396123-2395857 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T96912 NZ_CP026968:c2396123-2395857 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT96912 WP_000587616.1 NZ_CP026968:c2396380-2396123 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT96912 NZ_CP026968:c2396380-2396123 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3


Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References