Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 721494..721971 Replicon chromosome
Accession NZ_CP026968
Organism Staphylococcus aureus strain FDAARGOS_1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RK60_RS03750 Protein ID WP_000052076.1
Coordinates 721494..721682 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK60_RS03755 Protein ID WP_001059690.1
Coordinates 721711..721971 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK60_RS03720 717488..718009 + 522 WP_000824482.1 hypothetical protein -
RK60_RS03725 718350..719036 + 687 WP_000141557.1 thermonuclease family protein -
RK60_RS03730 719393..719593 + 201 WP_001059082.1 cold-shock protein -
RK60_RS03735 720085..720303 - 219 WP_000005886.1 hypothetical protein -
RK60_RS03740 720365..720649 - 285 WP_001004399.1 hypothetical protein -
RK60_RS03745 720737..721306 - 570 WP_001106654.1 hypothetical protein -
RK60_RS03750 721494..721682 - 189 WP_000052076.1 hypothetical protein Toxin
RK60_RS03755 721711..721971 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK60_RS03760 722312..722515 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK60_RS03765 722512..722748 - 237 WP_000349581.1 hypothetical protein -
RK60_RS03770 722973..723554 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK60_RS03775 723627..724244 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
RK60_RS03780 724399..724893 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK60_RS03785 725292..725714 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK60_RS03790 725862..726578 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T96897 WP_000052076.1 NZ_CP026968:c721682-721494 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T96897 NZ_CP026968:c721682-721494 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT96897 WP_001059690.1 NZ_CP026968:c721971-721711 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT96897 NZ_CP026968:c721971-721711 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References