Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 181693..182481 Replicon chromosome
Accession NZ_CP026968
Organism Staphylococcus aureus strain FDAARGOS_1

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag RK60_RS00835 Protein ID WP_000525004.1
Coordinates 181693..182154 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag RK60_RS00840 Protein ID WP_000333630.1
Coordinates 182167..182481 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK60_RS00810 178639..179844 - 1206 WP_016170637.1 site-specific integrase -
RK60_RS00815 179970..180584 + 615 WP_000191459.1 hypothetical protein -
RK60_RS00820 180581..180727 - 147 WP_001013104.1 hypothetical protein -
RK60_RS00825 180817..181212 - 396 WP_001558060.1 hypothetical protein -
RK60_RS00830 181241..181675 - 435 WP_016170817.1 hypothetical protein -
RK60_RS00835 181693..182154 - 462 WP_000525004.1 hypothetical protein Toxin
RK60_RS00840 182167..182481 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
RK60_RS00845 182633..182869 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
RK60_RS00850 182883..183659 + 777 WP_025176283.1 Rha family transcriptional regulator -
RK60_RS00855 183688..183831 + 144 WP_000939498.1 hypothetical protein -
RK60_RS00860 183821..184030 - 210 WP_000642492.1 hypothetical protein -
RK60_RS00865 184086..184331 + 246 WP_001025401.1 DUF2829 domain-containing protein -
RK60_RS00870 184300..184665 - 366 WP_016170627.1 hypothetical protein -
RK60_RS00875 184720..184935 + 216 WP_001097552.1 hypothetical protein -
RK60_RS00880 184960..185223 + 264 WP_001124160.1 helix-turn-helix domain-containing protein -
RK60_RS00885 185237..185398 + 162 WP_047211484.1 DUF1270 family protein -
RK60_RS00890 185490..185750 + 261 WP_000291090.1 DUF1108 family protein -
RK60_RS00895 185760..185981 + 222 WP_000815401.1 DUF2483 family protein -
RK60_RS00900 185974..186597 + 624 WP_000139720.1 DUF1071 domain-containing protein -
RK60_RS00905 186597..187025 + 429 WP_000934385.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 178639..222352 43713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T96893 WP_000525004.1 NZ_CP026968:c182154-181693 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T96893 NZ_CP026968:c182154-181693 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT96893 WP_000333630.1 NZ_CP026968:c182481-182167 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT96893 NZ_CP026968:c182481-182167 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References