96892

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2711115..2711592 Replicon chromosome
Accession NZ_CP026964
Organism Staphylococcus aureus strain FDAARGOS_2

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RK61_RS14050 Protein ID WP_000052076.1
Coordinates 2711404..2711592 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK61_RS14045 Protein ID WP_001059690.1
Coordinates 2711115..2711375 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK61_RS14010 2706534..2707250 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
RK61_RS14015 2707398..2707820 + 423 WP_000974464.1 organic hydroperoxide resistance protein -
RK61_RS14020 2708219..2708713 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK61_RS14025 2708868..2709485 + 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
RK61_RS14030 2709534..2710115 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
RK61_RS14035 2710339..2710575 + 237 WP_000368687.1 hypothetical protein -
RK61_RS14040 2710572..2710775 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK61_RS14045 2711115..2711375 + 261 WP_001059690.1 hypothetical protein Antitoxin
RK61_RS14050 2711404..2711592 + 189 WP_000052076.1 hypothetical protein Toxin
RK61_RS14055 2711780..2712349 + 570 WP_001106654.1 hypothetical protein -
RK61_RS14060 2712437..2712721 + 285 WP_001004401.1 hypothetical protein -
RK61_RS14065 2712783..2713001 + 219 WP_000005886.1 hypothetical protein -
RK61_RS14070 2713497..2713697 - 201 WP_001059082.1 cold-shock protein -
RK61_RS14075 2714054..2714740 - 687 WP_001793574.1 thermonuclease family protein -
RK61_RS14080 2715081..2715602 - 522 WP_000824464.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T96892 WP_000052076.1 NZ_CP026964:2711404-2711592 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T96892 NZ_CP026964:2711404-2711592 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT96892 WP_001059690.1 NZ_CP026964:2711115-2711375 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT96892 NZ_CP026964:2711115-2711375 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References