96884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1414021..1414535 Replicon chromosome
Accession NZ_CP026964
Organism Staphylococcus aureus strain FDAARGOS_2

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag RK61_RS07165 Protein ID WP_000581793.1
Coordinates 1414326..1414535 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag RK61_RS07160 Protein ID WP_000138932.1
Coordinates 1414021..1414314 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK61_RS07130 1409483..1410124 + 642 WP_000483155.1 thiamine phosphate synthase -
RK61_RS07135 1410210..1411082 + 873 WP_000725802.1 membrane protein insertase YidC -
RK61_RS07150 1411696..1412343 - 648 WP_001187628.1 HD domain-containing protein -
RK61_RS07155 1412371..1413855 - 1485 WP_000571549.1 cardiolipin synthase -
RK61_RS07160 1414021..1414314 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
RK61_RS07165 1414326..1414535 + 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
RK61_RS07170 1414663..1414800 + 138 WP_000828354.1 hypothetical protein -
RK61_RS07175 1415063..1416265 - 1203 WP_001109939.1 rod shape-determining protein RodA -
RK61_RS07180 1416562..1417632 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
RK61_RS07185 1417647..1419005 + 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T96884 WP_000581793.1 NZ_CP026964:1414326-1414535 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T96884 NZ_CP026964:1414326-1414535 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT96884 WP_000138932.1 NZ_CP026964:1414021-1414314 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT96884 NZ_CP026964:1414021-1414314 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References