Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 953750..954227 Replicon chromosome
Accession NZ_CP026962
Organism Staphylococcus aureus strain FDAARGOS_6

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RK64_RS04750 Protein ID WP_000052078.1
Coordinates 953750..953938 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK64_RS04755 Protein ID WP_001059690.1
Coordinates 953967..954227 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK64_RS04720 949791..950261 + 471 WP_000824472.1 hypothetical protein -
RK64_RS04725 950602..951288 + 687 WP_001548082.1 thermonuclease family protein -
RK64_RS04730 951645..951845 + 201 WP_001059082.1 cold-shock protein -
RK64_RS04735 952341..952559 - 219 WP_000005886.1 hypothetical protein -
RK64_RS04740 952621..952905 - 285 WP_001004395.1 hypothetical protein -
RK64_RS04745 952993..953562 - 570 WP_001106654.1 hypothetical protein -
RK64_RS04750 953750..953938 - 189 WP_000052078.1 hypothetical protein Toxin
RK64_RS04755 953967..954227 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK64_RS04760 954568..954771 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK64_RS04765 954768..955004 - 237 WP_000368687.1 hypothetical protein -
RK64_RS04770 955229..955810 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK64_RS04775 955883..956500 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RK64_RS04780 956655..957149 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK64_RS04785 957548..957970 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK64_RS04790 958118..958834 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T96865 WP_000052078.1 NZ_CP026962:c953938-953750 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T96865 NZ_CP026962:c953938-953750 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT96865 WP_001059690.1 NZ_CP026962:c954227-953967 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT96865 NZ_CP026962:c954227-953967 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References