Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1693750..1694227 Replicon chromosome
Accession NZ_CP026961
Organism Staphylococcus aureus strain FDAARGOS_10

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RK68_RS08990 Protein ID WP_000052078.1
Coordinates 1693750..1693938 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK68_RS08995 Protein ID WP_001059690.1
Coordinates 1693967..1694227 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK68_RS08960 1689791..1690261 + 471 WP_000824472.1 hypothetical protein -
RK68_RS08965 1690602..1691288 + 687 WP_001548082.1 thermonuclease family protein -
RK68_RS08970 1691645..1691845 + 201 WP_001059082.1 cold-shock protein -
RK68_RS08975 1692341..1692559 - 219 WP_000005886.1 hypothetical protein -
RK68_RS08980 1692621..1692905 - 285 WP_001004395.1 hypothetical protein -
RK68_RS08985 1692993..1693562 - 570 WP_001106654.1 hypothetical protein -
RK68_RS08990 1693750..1693938 - 189 WP_000052078.1 hypothetical protein Toxin
RK68_RS08995 1693967..1694227 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK68_RS09000 1694568..1694771 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK68_RS09005 1694768..1695004 - 237 WP_000368687.1 hypothetical protein -
RK68_RS09010 1695229..1695810 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK68_RS09015 1695883..1696500 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RK68_RS09020 1696655..1697149 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK68_RS09025 1697548..1697970 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK68_RS09030 1698118..1698834 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T96858 WP_000052078.1 NZ_CP026961:c1693938-1693750 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T96858 NZ_CP026961:c1693938-1693750 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT96858 WP_001059690.1 NZ_CP026961:c1694227-1693967 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT96858 NZ_CP026961:c1694227-1693967 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References