Detailed information of TA system TA096845

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2532311..2532828
• Replicon: chromosome
• Accession: NZ_CP026960
• Organism: Staphylococcus aureus strain FDAARGOS_15

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A2C9TUQ6
• Locus tag: RK73_RS13240
• Protein ID: WP_033863183.1
• Coordinates: 2532523..2532828 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: A0A2B8BQK3
• Locus tag: RK73_RS13235
• Protein ID: WP_001058490.1
• Coordinates: 2532311..2532520 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK73_RS13195	2527784..2528026	+	243	WP_000897044.1	30S ribosomal protein S18	-
RK73_RS13200	2528265..2529164	-	900	WP_001797289.1	Abi family protein	-
RK73_RS13205	2529166..2530380	-	1215	WP_000270124.1	site-specific integrase	-
RK73_RS13210	2530406..2531329	-	924	WP_050436923.1	helix-turn-helix domain-containing protein	-
RK73_RS13215	2531436..2531636	+	201	WP_001033058.1	helix-turn-helix domain-containing protein	-
RK73_RS13220	2531675..2531887	+	213	WP_033863184.1	helix-turn-helix transcriptional regulator	-
RK73_RS13225	2531888..2532160	+	273	WP_001138301.1	helix-turn-helix domain-containing protein	-
RK73_RS13230	2532172..2532318	+	147	WP_000784873.1	hypothetical protein	-
RK73_RS13235	2532311..2532520	+	210	WP_001058490.1	hypothetical protein	Antitoxin
RK73_RS13240	2532523..2532828	+	306	WP_033863183.1	DUF1474 family protein	Toxin
RK73_RS13245	2532903..2534516	+	1614	WP_033863178.1	hypothetical protein	-
RK73_RS13250	2534687..2535490	+	804	WP_033863177.1	bifunctional DNA primase/polymerase	-
RK73_RS14800	2535477..2535632	+	156	Protein_2474	pathogenicity island protein	-
RK73_RS14805	2535621..2535851	+	231	Protein_2475	virulence-associated protein E	-
RK73_RS13260	2536130..2536492	+	363	WP_001039168.1	hypothetical protein	-
RK73_RS13265	2536494..2536778	+	285	WP_033863176.1	hypothetical protein	-
RK73_RS13270	2536775..2537416	+	642	WP_033863175.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2527229..2548508	21279

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 12172.46 Da
• Isoelectric Point: 4.4054

>T96845 WP_033863183.1 NZ_CP026960:2532523-2532828 [Staphylococcus aureus]
MNLEIKDLFSDLKLLKDRFEDLKDNHGWHFEELYPHEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDA

Nucleotide

• Length: 306 bp

>T96845 NZ_CP026960:2532523-2532828 [Staphylococcus aureus]
ATGAATTTGGAAATTAAAGATTTGTTTAGCGATTTGAAATTGTTGAAAGATAGATTCGAAGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGCTATATCCACATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8153.17 Da
• Isoelectric Point: 4.3591

>AT96845 WP_001058490.1 NZ_CP026960:2532311-2532520 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLGKGE

Nucleotide

• Length: 210 bp

>AT96845 NZ_CP026960:2532311-2532520 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGGAAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A2C9TUQ6

Antitoxin

• AlphaFold DB: A0A2B8BQK3