96834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 190021..190498 Replicon chromosome
Accession NZ_CP026960
Organism Staphylococcus aureus strain FDAARGOS_15

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RK73_RS00965 Protein ID WP_000052078.1
Coordinates 190021..190209 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK73_RS00970 Protein ID WP_001059690.1
Coordinates 190238..190498 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK73_RS00935 186062..186532 + 471 WP_000824472.1 hypothetical protein -
RK73_RS00940 186873..187559 + 687 WP_001548082.1 thermonuclease family protein -
RK73_RS00945 187916..188116 + 201 WP_001059082.1 cold-shock protein -
RK73_RS00950 188612..188830 - 219 WP_000005886.1 hypothetical protein -
RK73_RS00955 188892..189176 - 285 WP_001004395.1 hypothetical protein -
RK73_RS00960 189264..189833 - 570 WP_001106654.1 hypothetical protein -
RK73_RS00965 190021..190209 - 189 WP_000052078.1 hypothetical protein Toxin
RK73_RS00970 190238..190498 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK73_RS00975 190839..191042 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK73_RS00980 191039..191275 - 237 WP_000368687.1 hypothetical protein -
RK73_RS00985 191500..192081 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK73_RS00990 192154..192771 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RK73_RS00995 192926..193420 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK73_RS01000 193819..194241 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK73_RS01005 194389..195105 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T96834 WP_000052078.1 NZ_CP026960:c190209-190021 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T96834 NZ_CP026960:c190209-190021 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT96834 WP_001059690.1 NZ_CP026960:c190498-190238 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT96834 NZ_CP026960:c190498-190238 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References