Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1963552..1964029 Replicon chromosome
Accession NZ_CP026958
Organism Staphylococcus aureus strain FDAARGOS_40

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RK98_RS10350 Protein ID WP_000052076.1
Coordinates 1963552..1963740 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK98_RS10355 Protein ID WP_001059690.1
Coordinates 1963769..1964029 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK98_RS10320 1959546..1960067 + 522 WP_000824482.1 hypothetical protein -
RK98_RS10325 1960408..1961094 + 687 WP_000141557.1 thermonuclease family protein -
RK98_RS10330 1961451..1961651 + 201 WP_001059082.1 cold-shock protein -
RK98_RS10335 1962143..1962361 - 219 WP_000005886.1 hypothetical protein -
RK98_RS10340 1962423..1962707 - 285 WP_001004399.1 hypothetical protein -
RK98_RS10345 1962795..1963364 - 570 WP_001106654.1 hypothetical protein -
RK98_RS10350 1963552..1963740 - 189 WP_000052076.1 hypothetical protein Toxin
RK98_RS10355 1963769..1964029 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK98_RS10360 1964370..1964573 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK98_RS10365 1964570..1964806 - 237 WP_000349581.1 hypothetical protein -
RK98_RS10370 1965031..1965612 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK98_RS10375 1965685..1966302 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
RK98_RS10380 1966457..1966951 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK98_RS10385 1967350..1967772 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK98_RS10390 1967920..1968636 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T96833 WP_000052076.1 NZ_CP026958:c1963740-1963552 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T96833 NZ_CP026958:c1963740-1963552 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT96833 WP_001059690.1 NZ_CP026958:c1964029-1963769 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT96833 NZ_CP026958:c1964029-1963769 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References