Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1937128..1937666 Replicon chromosome
Accession NZ_CP026958
Organism Staphylococcus aureus strain FDAARGOS_40

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag RK98_RS10190 Protein ID WP_001078344.1
Coordinates 1937340..1937666 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A0H3JSN0
Locus tag RK98_RS10185 Protein ID WP_001058495.1
Coordinates 1937128..1937337 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK98_RS10150 1932374..1932658 + 285 WP_000917289.1 co-chaperone GroES -
RK98_RS10155 1932734..1934350 + 1617 WP_000240642.1 chaperonin GroEL -
RK98_RS10160 1934419..1935591 - 1173 WP_000179343.1 site-specific integrase -
RK98_RS10165 1935605..1936279 - 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
RK98_RS10170 1936452..1936670 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
RK98_RS10175 1936675..1936992 + 318 WP_000481967.1 helix-turn-helix domain-containing protein -
RK98_RS10180 1936989..1937135 + 147 WP_000784885.1 hypothetical protein -
RK98_RS10185 1937128..1937337 + 210 WP_001058495.1 hypothetical protein Antitoxin
RK98_RS10190 1937340..1937666 + 327 WP_001078344.1 DUF1474 family protein Toxin
RK98_RS10195 1937731..1938600 + 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
RK98_RS10200 1938614..1940323 + 1710 WP_000447473.1 DUF927 domain-containing protein -
RK98_RS10205 1940633..1941013 + 381 WP_000356942.1 hypothetical protein -
RK98_RS10210 1941010..1941651 + 642 WP_001047698.1 hypothetical protein -
RK98_RS10215 1942101..1942442 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T96832 WP_001078344.1 NZ_CP026958:1937340-1937666 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T96832 NZ_CP026958:1937340-1937666 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8206.22 Da        Isoelectric Point: 4.3718

>AT96832 WP_001058495.1 NZ_CP026958:1937128-1937337 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT96832 NZ_CP026958:1937128-1937337 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3JSN0

References