Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 333077..333606 Replicon chromosome
Accession NZ_CP026958
Organism Staphylococcus aureus strain FDAARGOS_40

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag RK98_RS01990 Protein ID WP_001103933.1
Coordinates 333077..333394 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag RK98_RS01995 Protein ID WP_001058487.1
Coordinates 333397..333606 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK98_RS01955 328292..328633 - 342 WP_001190615.1 hypothetical protein -
RK98_RS01960 329083..329724 - 642 WP_001019810.1 hypothetical protein -
RK98_RS01965 329721..330005 - 285 WP_000998179.1 hypothetical protein -
RK98_RS01970 330007..330369 - 363 WP_001039169.1 hypothetical protein -
RK98_RS01980 330655..332124 - 1470 WP_001668899.1 virulence-associated E family protein -
RK98_RS01985 332141..333010 - 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
RK98_RS01990 333077..333394 - 318 WP_001103933.1 DUF1474 family protein Toxin
RK98_RS01995 333397..333606 - 210 WP_001058487.1 hypothetical protein Antitoxin
RK98_RS02000 333599..333745 - 147 WP_000784893.1 hypothetical protein -
RK98_RS02005 333742..333969 - 228 WP_000164237.1 helix-turn-helix domain-containing protein -
RK98_RS02010 334005..334211 - 207 WP_001060953.1 hypothetical protein -
RK98_RS02015 334369..335016 + 648 WP_072474260.1 helix-turn-helix domain-containing protein -
RK98_RS02020 335022..336128 + 1107 WP_000121223.1 site-specific integrase -
RK98_RS02030 336691..337155 - 465 WP_001085183.1 SsrA-binding protein SmpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / sea / hlb / sell / sec / tsst-1 271927..339549 67622


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T96821 WP_001103933.1 NZ_CP026958:c333394-333077 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T96821 NZ_CP026958:c333394-333077 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT96821 WP_001058487.1 NZ_CP026958:c333606-333397 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT96821 NZ_CP026958:c333606-333397 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References