Detailed information of TA system TA096799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 562417..563214
• Replicon: chromosome
• Accession: NZ_CP026957
• Organism: Staphylococcus aureus strain FDAARGOS_43

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A6K0KKW3
• Locus tag: RL01_RS03190
• Protein ID: WP_000525002.1
• Coordinates: 562417..562878 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: RL01_RS03195
• Protein ID: WP_001260485.1
• Coordinates: 562891..563214 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL01_RS03170	559404..560609	-	1206	WP_000264191.1	site-specific integrase	-
RL01_RS03175	560719..561342	+	624	WP_001166482.1	hypothetical protein	-
RL01_RS03180	561541..561936	-	396	WP_000449653.1	hypothetical protein	-
RL01_RS03185	561965..562399	-	435	WP_000755718.1	hypothetical protein	-
RL01_RS03190	562417..562878	-	462	WP_000525002.1	hypothetical protein	Toxin
RL01_RS03195	562891..563214	-	324	WP_001260485.1	helix-turn-helix domain-containing protein	Antitoxin
RL01_RS03200	563378..563626	+	249	WP_000272860.1	helix-turn-helix domain-containing protein	-
RL01_RS03205	563642..563887	+	246	WP_001025401.1	DUF2829 domain-containing protein	-
RL01_RS03210	563856..564221	-	366	WP_001128433.1	hypothetical protein	-
RL01_RS03215	564276..564491	+	216	WP_001036302.1	hypothetical protein	-
RL01_RS03220	564516..564779	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
RL01_RS03225	564792..564953	+	162	WP_001285963.1	DUF1270 family protein	-
RL01_RS03230	565032..565355	+	324	WP_000174994.1	hypothetical protein	-
RL01_RS03235	565370..565732	+	363	WP_000985979.1	hypothetical protein	-
RL01_RS03240	565729..566895	+	1167	WP_000762552.1	DUF2800 domain-containing protein	-
RL01_RS03245	566921..567478	+	558	WP_000645048.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 17943.33 Da
• Isoelectric Point: 5.0698

>T96799 WP_000525002.1 NZ_CP026957:c562878-562417 [Staphylococcus aureus]
MGLYEETLIQHAYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T96799 NZ_CP026957:c562878-562417 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGCTTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCTGTACCGCTACATGAAATTGTAGAAGCTCACAACTACGGTGTTCGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12439.16 Da
• Isoelectric Point: 9.3811

>AT96799 WP_001260485.1 NZ_CP026957:c563214-562891 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT96799 NZ_CP026957:c563214-562891 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAT
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCTGATTATATAAGAAGCAAACGTAA
GTAA

Structures

Toxin

• AlphaFold DB: A0A6K0KKW3