Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2150818..2151295 Replicon chromosome
Accession NZ_CP026953
Organism Staphylococcus aureus strain FDAARGOS_48

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RL06_RS11385 Protein ID WP_000052076.1
Coordinates 2150818..2151006 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RL06_RS11390 Protein ID WP_001059690.1
Coordinates 2151035..2151295 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL06_RS11355 2146812..2147333 + 522 WP_000824482.1 hypothetical protein -
RL06_RS11360 2147674..2148360 + 687 WP_000141557.1 thermonuclease family protein -
RL06_RS11365 2148717..2148917 + 201 WP_001059082.1 cold-shock protein -
RL06_RS11370 2149409..2149627 - 219 WP_000005886.1 hypothetical protein -
RL06_RS11375 2149689..2149973 - 285 WP_001004399.1 hypothetical protein -
RL06_RS11380 2150061..2150630 - 570 WP_001106654.1 hypothetical protein -
RL06_RS11385 2150818..2151006 - 189 WP_000052076.1 hypothetical protein Toxin
RL06_RS11390 2151035..2151295 - 261 WP_001059690.1 hypothetical protein Antitoxin
RL06_RS11395 2151636..2151839 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RL06_RS11400 2151836..2152072 - 237 WP_000349581.1 hypothetical protein -
RL06_RS11405 2152297..2152878 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RL06_RS11410 2152951..2153568 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
RL06_RS11415 2153723..2154217 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RL06_RS11420 2154616..2155038 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RL06_RS11425 2155186..2155902 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T96792 WP_000052076.1 NZ_CP026953:c2151006-2150818 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T96792 NZ_CP026953:c2151006-2150818 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT96792 WP_001059690.1 NZ_CP026953:c2151295-2151035 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT96792 NZ_CP026953:c2151295-2151035 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References