Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1616230..1617018 Replicon chromosome
Accession NZ_CP026953
Organism Staphylococcus aureus strain FDAARGOS_48

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag RL06_RS08490 Protein ID WP_000525004.1
Coordinates 1616230..1616691 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag RL06_RS08495 Protein ID WP_000333630.1
Coordinates 1616704..1617018 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL06_RS08465 1613176..1614381 - 1206 WP_016170637.1 site-specific integrase -
RL06_RS08470 1614507..1615121 + 615 WP_000191459.1 hypothetical protein -
RL06_RS08475 1615118..1615264 - 147 WP_001013104.1 hypothetical protein -
RL06_RS08480 1615354..1615749 - 396 WP_001558060.1 hypothetical protein -
RL06_RS08485 1615778..1616212 - 435 WP_016170817.1 hypothetical protein -
RL06_RS08490 1616230..1616691 - 462 WP_000525004.1 hypothetical protein Toxin
RL06_RS08495 1616704..1617018 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
RL06_RS08500 1617170..1617406 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
RL06_RS08505 1617420..1618196 + 777 WP_025176283.1 Rha family transcriptional regulator -
RL06_RS08510 1618225..1618368 + 144 WP_000939498.1 hypothetical protein -
RL06_RS08515 1618358..1618567 - 210 WP_000642492.1 hypothetical protein -
RL06_RS08520 1618623..1618868 + 246 WP_001025401.1 DUF2829 domain-containing protein -
RL06_RS08525 1618837..1619202 - 366 WP_016170627.1 hypothetical protein -
RL06_RS08530 1619257..1619472 + 216 WP_001097552.1 hypothetical protein -
RL06_RS08535 1619497..1619760 + 264 WP_001124160.1 helix-turn-helix domain-containing protein -
RL06_RS08540 1619774..1619935 + 162 WP_047211484.1 DUF1270 family protein -
RL06_RS08545 1620027..1620287 + 261 WP_000291090.1 DUF1108 family protein -
RL06_RS08550 1620297..1620518 + 222 WP_000815401.1 DUF2483 family protein -
RL06_RS08555 1620511..1621134 + 624 WP_000139720.1 DUF1071 domain-containing protein -
RL06_RS08560 1621134..1621562 + 429 WP_000934385.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - geh 1603930..1656889 52959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T96788 WP_000525004.1 NZ_CP026953:c1616691-1616230 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T96788 NZ_CP026953:c1616691-1616230 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT96788 WP_000333630.1 NZ_CP026953:c1617018-1616704 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT96788 NZ_CP026953:c1617018-1616704 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References