Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1978444..1979275 Replicon chromosome
Accession NZ_CP026935
Organism Escherichia coli strain CFS3292

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag C5F72_RS09495 Protein ID WP_000854814.1
Coordinates 1978444..1978818 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag C5F72_RS09500 Protein ID WP_001285585.1
Coordinates 1978907..1979275 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5F72_RS09455 1973840..1975006 + 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
C5F72_RS09460 1975125..1975598 + 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
C5F72_RS09465 1975796..1976854 + 1059 WP_001200891.1 FUSC family protein -
C5F72_RS09470 1977026..1977355 + 330 WP_000450409.1 DUF496 family protein -
C5F72_RS09475 1977456..1977638 - 183 WP_001016348.1 hypothetical protein -
C5F72_RS09480 1977710..1977838 + 129 Protein_1857 transposase domain-containing protein -
C5F72_RS09485 1978127..1978240 - 114 WP_001161660.1 DUF957 domain-containing protein -
C5F72_RS09490 1978253..1978447 - 195 WP_000988600.1 hypothetical protein -
C5F72_RS09495 1978444..1978818 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
C5F72_RS09500 1978907..1979275 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
C5F72_RS09505 1979349..1979570 - 222 WP_000692323.1 DUF987 domain-containing protein -
C5F72_RS09510 1979633..1980109 - 477 WP_001186726.1 RadC family protein -
C5F72_RS09515 1980125..1980604 - 480 WP_000860087.1 antirestriction protein -
C5F72_RS09520 1980686..1981504 - 819 WP_054472832.1 DUF945 domain-containing protein -
C5F72_RS09525 1981604..1981837 - 234 WP_001119729.1 DUF905 family protein -
C5F72_RS09530 1981916..1982371 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T96709 WP_000854814.1 NZ_CP026935:c1978818-1978444 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T96709 NZ_CP026935:c1978818-1978444 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT96709 WP_001285585.1 NZ_CP026935:c1979275-1978907 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT96709 NZ_CP026935:c1979275-1978907 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References