Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4543704..4544502 Replicon chromosome
Accession NZ_CP026932
Organism Escherichia coli strain CFS3273

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag C5F73_RS21845 Protein ID WP_000854735.1
Coordinates 4544125..4544502 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag C5F73_RS21840 Protein ID WP_001285415.1
Coordinates 4543704..4544078 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5F73_RS21805 4539460..4540344 + 885 WP_000010403.1 50S ribosome-binding GTPase -
C5F73_RS21810 4540463..4541140 + 678 WP_001562086.1 hypothetical protein -
C5F73_RS21815 4541146..4541379 + 234 WP_001278287.1 DUF905 family protein -
C5F73_RS21820 4541469..4542287 + 819 WP_001175148.1 DUF945 domain-containing protein -
C5F73_RS21825 4542369..4542848 + 480 WP_000844100.1 antirestriction protein -
C5F73_RS21830 4542864..4543340 + 477 WP_001366855.1 RadC family protein -
C5F73_RS21835 4543403..4543624 + 222 WP_000692309.1 DUF987 domain-containing protein -
C5F73_RS21840 4543704..4544078 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C5F73_RS21845 4544125..4544502 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
C5F73_RS21850 4544499..4544987 + 489 WP_000761677.1 hypothetical protein -
C5F73_RS21855 4544999..4545196 + 198 WP_000839291.1 DUF957 domain-containing protein -
C5F73_RS21860 4545281..4546147 + 867 WP_001280433.1 DUF4942 domain-containing protein -
C5F73_RS21865 4546219..4546482 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
C5F73_RS21870 4546479..4546805 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
C5F73_RS21875 4547269..4548534 + 1266 WP_001218793.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4542369..4564137 21768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T96684 WP_000854735.1 NZ_CP026932:4544125-4544502 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T96684 NZ_CP026932:4544125-4544502 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT96684 WP_001285415.1 NZ_CP026932:4543704-4544078 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT96684 NZ_CP026932:4543704-4544078 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References