Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1825..2360 Replicon plasmid pCFS3246-2
Accession NZ_CP026931
Organism Escherichia coli strain CFS3246

Toxin (Protein)


Gene name relE Uniprot ID A0A221ZN37
Locus tag C4962_RS23940 Protein ID WP_000222768.1
Coordinates 2073..2360 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag C4962_RS23935 Protein ID WP_001132900.1
Coordinates 1825..2076 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4962_RS24465 1561..1701 + 141 WP_165488741.1 hypothetical protein -
C4962_RS23935 1825..2076 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C4962_RS23940 2073..2360 + 288 WP_000222768.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4962_RS23945 3506..4849 + 1344 WP_140431778.1 hypothetical protein -
C4962_RS23950 5062..5412 + 351 Protein_5 DUF1281 domain-containing protein -
C4962_RS23955 5982..6326 - 345 WP_053913472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..62468 62468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11115.13 Da        Isoelectric Point: 10.4701

>T96658 WP_000222768.1 NZ_CP026931:2073-2360 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKVIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T96658 NZ_CP026931:2073-2360 [Escherichia coli]
ATGACTTATACGGTCAAATTCAGAGATGATGCGCTGAAAGAGTGGCTGAAGCTGGATAAAGTCATTCAACAGCAATTTGC
GAAAAAGCTAAAGAAGTGCAGTGAAAATCCGCACATCCCTTCAGCAAAACTGCGAGGGATAAAGGACTGCTACAAAATCA
AGCTTCGAGCCTCTGGTTTTCGTCTGGTCTATCAGGTGATTGACGATCAATTAATTATCGCTGTTGTAGCTGTAGGAAAA
CGTGAACGTAGTGACGTTTATAATCTTGCCAGTGAGCGAATGAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT96658 WP_001132900.1 NZ_CP026931:1825-2076 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT96658 NZ_CP026931:1825-2076 [Escherichia coli]
ATGCCTAACATTATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATCCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGATCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A221ZN37

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References