Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/ElaA-DUF1778
Location 9127..9930 Replicon plasmid pCFS3246-1
Accession NZ_CP026930
Organism Escherichia coli strain CFS3246

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag C4962_RS23185 Protein ID WP_000348879.1
Coordinates 9127..9657 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag C4962_RS23190 Protein ID WP_000114669.1
Coordinates 9661..9930 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4962_RS23150 4295..4537 + 243 WP_000470771.1 hypothetical protein -
C4962_RS23155 4605..4880 - 276 WP_000662184.1 hypothetical protein -
C4962_RS23165 6136..6372 + 237 WP_032215364.1 hypothetical protein -
C4962_RS23170 6529..7062 + 534 WP_032235482.1 hypothetical protein -
C4962_RS23175 7140..7948 + 809 Protein_9 fimbria/pilus outer membrane usher protein -
C4962_RS23180 7948..8645 - 698 Protein_10 IS1 family transposase -
C4962_RS23185 9127..9657 - 531 WP_000348879.1 GNAT family N-acetyltransferase Toxin
C4962_RS23190 9661..9930 - 270 WP_000114669.1 DUF1778 domain-containing protein Antitoxin
C4962_RS23195 10123..10619 - 497 Protein_13 tyrosine-type recombinase/integrase -
C4962_RS23200 10780..11307 - 528 WP_000592915.1 hypothetical protein -
C4962_RS23205 11300..11824 - 525 WP_000737845.1 type 1 fimbrial protein -
C4962_RS23210 11824..12825 - 1002 WP_000792596.1 protein FanF -
C4962_RS23215 12825..13511 - 687 WP_001031857.1 fimbrial chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / aph(3'')-Ib / aph(6)-Id estIa / paa 1..129225 129225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(92-156)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 20402.29 Da        Isoelectric Point: 6.6389

>T96646 WP_000348879.1 NZ_CP026930:c9657-9127 [Escherichia coli]
MDGLRIEIFSEEVEYELSNFDCGEEYLNTFLTDHLKRQHNSKILRGYLLVTREDKPRVMGYYTLSGSCFEKTLLPSKTQQ
KRVPYKNVPSVTLGRLAIDKNLHRQGYGETLVTHAMKVVYQASQAVGIHGMFVEALNDNAKKFYLRMGFIQLKEENCNSL
FYPTKSIEELFEVNDE

Download         Length: 531 bp

>T96646 NZ_CP026930:c9657-9127 [Escherichia coli]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGAAACGTCAGCACAACAGTAAGATTTTACGTGGTTATCTGCTCGTGACGAGAGAGG
ATAAACCACGTGTCATGGGGTACTACACTCTGTCTGGCAGTTGTTTTGAGAAAACACTTCTACCCAGCAAAACACAACAA
AAGCGTGTGCCCTATAAAAATGTTCCTAGTGTGACTTTGGGCCGTCTGGCAATTGATAAAAATCTTCATCGCCAGGGATA
TGGAGAAACACTTGTTACTCATGCTATGAAAGTTGTGTATCAGGCCTCGCAAGCTGTGGGTATACACGGAATGTTCGTGG
AAGCACTGAACGACAACGCCAAAAAGTTCTACCTTCGAATGGGTTTTATACAGTTAAAGGAAGAAAACTGTAATTCGCTC
TTCTACCCGACAAAATCTATTGAAGAATTGTTCGAAGTAAATGATGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10341.85 Da        Isoelectric Point: 6.4742

>AT96646 WP_000114669.1 NZ_CP026930:c9930-9661 [Escherichia coli]
MSVLKKQRIDLRLNEDDKHMIEEAAAMTNQSISQFMVSTASERAAEVIDQHRRLLLNEESWNLVMDAITNPPVPNERLKR
AAKRLRELE

Download         Length: 270 bp

>AT96646 NZ_CP026930:c9930-9661 [Escherichia coli]
ATGTCAGTACTGAAAAAGCAGCGCATAGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCAATCTCACAGTTTATGGTCAGTACCGCTTCAGAACGCGCTGCAGAAGTTATTGATCAGCACCGTCGAC
TGCTCCTTAATGAGGAGTCATGGAACCTGGTTATGGATGCCATCACTAATCCGCCAGTACCAAATGAACGACTGAAACGA
GCCGCTAAACGTCTCCGGGAACTGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References