Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2383400..2383926 | Replicon | chromosome |
| Accession | NZ_CP026929 | ||
| Organism | Escherichia coli strain CFS3246 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | C4962_RS11660 | Protein ID | WP_000323025.1 |
| Coordinates | 2383639..2383926 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | C4962_RS11655 | Protein ID | WP_000534858.1 |
| Coordinates | 2383400..2383639 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C4962_RS11625 | 2378759..2379106 | - | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| C4962_RS11630 | 2379103..2379507 | - | 405 | WP_000839179.1 | IS66 family insertion sequence hypothetical protein | - |
| C4962_RS24395 | 2380232..2380450 | + | 219 | WP_072096395.1 | hypothetical protein | - |
| C4962_RS11635 | 2380425..2380607 | - | 183 | WP_000955178.1 | hypothetical protein | - |
| C4962_RS11640 | 2380785..2382098 | + | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| C4962_RS11645 | 2382535..2382867 | - | 333 | WP_001301033.1 | protein FlxA | - |
| C4962_RS11650 | 2383070..2383375 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| C4962_RS11655 | 2383400..2383639 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| C4962_RS11660 | 2383639..2383926 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| C4962_RS11665 | 2383998..2384153 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| C4962_RS11670 | 2384370..2384621 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| C4962_RS11675 | 2384688..2384966 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| C4962_RS11680 | 2384968..2386017 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| C4962_RS11685 | 2386031..2386783 | + | 753 | WP_001047135.1 | antitermination protein | - |
| C4962_RS11690 | 2387061..2387150 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| C4962_RS11695 | 2387205..2387417 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| C4962_RS11700 | 2387718..2387933 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| C4962_RS11705 | 2388687..2388902 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2366408..2419338 | 52930 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T96637 WP_000323025.1 NZ_CP026929:2383639-2383926 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T96637 NZ_CP026929:2383639-2383926 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT96637 WP_000534858.1 NZ_CP026929:2383400-2383639 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT96637 NZ_CP026929:2383400-2383639 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|