Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 61325..61950 Replicon plasmid unnamed
Accession NZ_CP026879
Organism Shigella dysenteriae strain 07-3308

Toxin (Protein)


Gene name vapC Uniprot ID A0A090N9J2
Locus tag C1P62_RS24340 Protein ID WP_000911312.1
Coordinates 61552..61950 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q326X5
Locus tag C1P62_RS24335 Protein ID WP_000450529.1
Coordinates 61325..61552 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P62_RS24330 60824..61243 - 420 WP_011379018.1 conjugative relaxase -
C1P62_RS24335 61325..61552 + 228 WP_000450529.1 toxin-antitoxin system antitoxin VapB Antitoxin
C1P62_RS24340 61552..61950 + 399 WP_000911312.1 tRNA(fMet)-specific endonuclease VapC Toxin
C1P62_RS24345 61959..63740 - 1782 Protein_79 type IV conjugative transfer system coupling protein TraD -
C1P62_RS24350 63806..64962 + 1157 WP_134806340.1 IS3 family transposase -
C1P62_RS24355 64987..65759 - 773 Protein_81 transposase -
C1P62_RS24360 65932..66354 + 423 Protein_82 hypothetical protein -
C1P62_RS25960 66499..66630 - 132 Protein_83 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospG / ipaH9.8 / ospI / ospC2 / ospD3/senA / ospC1 1..69799 69799


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14869.20 Da        Isoelectric Point: 8.5264

>T96531 WP_000911312.1 NZ_CP026879:61552-61950 [Shigella dysenteriae]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAAIHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

>T96531 NZ_CP026879:61552-61950 [Shigella dysenteriae]
ATGCTGAAGTTTATGCTCGATACCAACATCTGTATTTTTACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTTAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCCGCTGCAGCCATACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGGCTGATTATTGTGACTAACAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8593.63 Da        Isoelectric Point: 4.5680

>AT96531 WP_000450529.1 NZ_CP026879:61325-61552 [Shigella dysenteriae]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHSVSADFMDNREQPDMQERESF

Download         Length: 228 bp

>AT96531 NZ_CP026879:61325-61552 [Shigella dysenteriae]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAGCGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGACATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090N9J2

Antitoxin

Source ID Structure
AlphaFold DB A0A090NVK5

References