Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 15771..16330 | Replicon | plasmid unnamed |
| Accession | NZ_CP026879 | ||
| Organism | Shigella dysenteriae strain 07-3308 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q327A7 |
| Locus tag | C1P62_RS24020 | Protein ID | WP_000421263.1 |
| Coordinates | 15771..16046 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q327A8 |
| Locus tag | C1P62_RS24025 | Protein ID | WP_001178088.1 |
| Coordinates | 16046..16330 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1P62_RS23985 | 11411..11506 | - | 96 | Protein_13 | transposase domain-containing protein | - |
| C1P62_RS23990 | 11542..11847 | - | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | - |
| C1P62_RS23995 | 11849..12067 | - | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| C1P62_RS24000 | 12307..13000 | + | 694 | Protein_16 | IS1 family transposase | - |
| C1P62_RS24005 | 13376..14466 | - | 1091 | Protein_17 | IS66 family transposase | - |
| C1P62_RS24010 | 14474..15042 | + | 569 | Protein_18 | plasmid segregation protein ParM | - |
| C1P62_RS24015 | 15045..15410 | + | 366 | WP_000361391.1 | plasmid partitioning/stability family protein | - |
| C1P62_RS25835 | 15502..15639 | + | 138 | WP_000766699.1 | hypothetical protein | - |
| C1P62_RS24020 | 15771..16046 | - | 276 | WP_000421263.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| C1P62_RS24025 | 16046..16330 | - | 285 | WP_001178088.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| C1P62_RS24040 | 17082..17291 | + | 210 | Protein_23 | peptidoglycan-binding protein | - |
| C1P62_RS24045 | 17391..17576 | - | 186 | Protein_24 | ATP-binding protein | - |
| C1P62_RS24055 | 17912..18381 | + | 470 | Protein_25 | IS1 family transposase | - |
| C1P62_RS25840 | 18540..19178 | + | 639 | WP_000607008.1 | type III secretion system effector OspI | - |
| C1P62_RS24065 | 19293..19826 | + | 534 | Protein_27 | transposase | - |
| C1P62_RS25845 | 19880..20020 | + | 141 | Protein_28 | IS3 family transposase | - |
| C1P62_RS24070 | 20085..20485 | + | 401 | Protein_29 | transposase | - |
| C1P62_RS24075 | 20541..21237 | + | 697 | Protein_30 | IS1 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ospG / ipaH9.8 / ospI / ospC2 / ospD3/senA / ospC1 | 1..69799 | 69799 | |
| - | inside | IScluster/Tn | - | ospG / ipaH9.8 / ospI / ospC2 | 5388..36922 | 31534 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10792.51 Da Isoelectric Point: 9.8135
>T96530 WP_000421263.1 NZ_CP026879:c16046-15771 [Shigella dysenteriae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWYTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWYTRENR
Download Length: 276 bp
>T96530 NZ_CP026879:c16046-15771 [Shigella dysenteriae]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTAGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGTACACACGAGAGAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTAGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGTACACACGAGAGAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10497.93 Da Isoelectric Point: 6.2150
>AT96530 WP_001178088.1 NZ_CP026879:c16330-16046 [Shigella dysenteriae]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
Download Length: 285 bp
>AT96530 NZ_CP026879:c16330-16046 [Shigella dysenteriae]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|