Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1640997..1641795 | Replicon | chromosome |
| Accession | NZ_CP026878 | ||
| Organism | Shigella dysenteriae strain 07-3308 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q32HN1 |
| Locus tag | C1P62_RS09210 | Protein ID | WP_001094433.1 |
| Coordinates | 1641421..1641795 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | Q32HN0 |
| Locus tag | C1P62_RS09205 | Protein ID | WP_001285603.1 |
| Coordinates | 1640997..1641374 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1P62_RS09155 | 1636178..1636645 | + | 468 | WP_000668907.1 | hypothetical protein | - |
| C1P62_RS09160 | 1637076..1637559 | + | 484 | Protein_1742 | hypothetical protein | - |
| C1P62_RS09165 | 1637679..1637852 | + | 174 | WP_000088742.1 | DUF905 family protein | - |
| C1P62_RS09175 | 1637953..1638773 | + | 821 | Protein_1744 | DUF945 domain-containing protein | - |
| C1P62_RS09185 | 1639053..1639526 | + | 474 | WP_001313575.1 | antirestriction protein | - |
| C1P62_RS09190 | 1639542..1639994 | + | 453 | WP_134806258.1 | RadC family protein | - |
| C1P62_RS09195 | 1640063..1640284 | + | 222 | WP_000692331.1 | DUF987 domain-containing protein | - |
| C1P62_RS09200 | 1640303..1640947 | + | 645 | WP_000086764.1 | hypothetical protein | - |
| C1P62_RS09205 | 1640997..1641374 | + | 378 | WP_001285603.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C1P62_RS09210 | 1641421..1641795 | + | 375 | WP_001094433.1 | toxin | Toxin |
| C1P62_RS09215 | 1641792..1642283 | + | 492 | WP_000976859.1 | hypothetical protein | - |
| C1P62_RS09220 | 1642295..1642492 | + | 198 | WP_000839257.1 | DUF957 domain-containing protein | - |
| C1P62_RS09225 | 1642589..1643431 | + | 843 | WP_005020348.1 | DUF4942 domain-containing protein | - |
| C1P62_RS09235 | 1643902..1644840 | + | 939 | WP_000351336.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| C1P62_RS09240 | 1644895..1645632 | + | 738 | WP_000283663.1 | zinc-binding phosphatase | - |
| C1P62_RS09245 | 1645656..1646210 | + | 555 | WP_001001927.1 | molecular chaperone YcdY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fliA / fliC / ipaH9.8 / ipaH9.8 / rcsA / iroB / iroC / iroD / iroD / iroE / iroN / iroN / csgG / csgF / csgE / csgD | 1564097..1658931 | 94834 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13918.86 Da Isoelectric Point: 6.8517
>T96521 WP_001094433.1 NZ_CP026878:1641421-1641795 [Shigella dysenteriae]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T96521 NZ_CP026878:1641421-1641795 [Shigella dysenteriae]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13789.72 Da Isoelectric Point: 6.4643
>AT96521 WP_001285603.1 NZ_CP026878:1640997-1641374 [Shigella dysenteriae]
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT96521 NZ_CP026878:1640997-1641374 [Shigella dysenteriae]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A090NBY3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A090NW75 |