Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelE-RHH |
Location | 67841..68388 | Replicon | plasmid pMS7163A |
Accession | NZ_CP026854 | ||
Organism | Escherichia coli strain MS7163 |
Toxin (Protein)
Gene name | parE | Uniprot ID | E9LLH3 |
Locus tag | MS7163_RS27085 | Protein ID | WP_000969996.1 |
Coordinates | 68107..68388 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | E1QMW3 |
Locus tag | MS7163_RS27080 | Protein ID | WP_000079941.1 |
Coordinates | 67841..68110 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MS7163_RS27030 | 63115..63861 | + | 747 | WP_000205759.1 | conjugal transfer pilus acetylase TraX | - |
MS7163_RS27035 | 63916..64476 | + | 561 | WP_000139359.1 | fertility inhibition protein FinO | - |
MS7163_RS27040 | 64614..64826 | + | 213 | WP_001311693.1 | hypothetical protein | - |
MS7163_RS27045 | 65069..65470 | + | 402 | WP_001233870.1 | thermonuclease family protein | - |
MS7163_RS27050 | 65515..65775 | + | 261 | WP_000083818.1 | replication regulatory protein RepA | - |
MS7163_RS27060 | 66001..66075 | + | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
MS7163_RS27065 | 66068..66925 | + | 858 | WP_000130940.1 | incFII family plasmid replication initiator RepA | - |
MS7163_RS27080 | 67841..68110 | + | 270 | WP_000079941.1 | hypothetical protein | Antitoxin |
MS7163_RS27085 | 68107..68388 | + | 282 | WP_000969996.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MS7163_RS27090 | 68434..69282 | + | 849 | WP_001057989.1 | 3'-5' exonuclease | - |
MS7163_RS27095 | 69468..71348 | + | 1881 | WP_001283335.1 | colicin | - |
MS7163_RS27100 | 71370..71705 | - | 336 | WP_001080729.1 | colicin 1A immunity protein | - |
MS7163_RS27110 | 71834..72091 | + | 258 | WP_000142431.1 | hypothetical protein | - |
MS7163_RS27115 | 72111..72701 | - | 591 | WP_001350923.1 | hypothetical protein | - |
MS7163_RS27120 | 72698..72958 | - | 261 | WP_000343091.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | sitABCD | iroN / iroE / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA | 1..133843 | 133843 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10893.57 Da Isoelectric Point: 8.4615
>T96509 WP_000969996.1 NZ_CP026854:68107-68388 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP
Download Length: 282 bp
>T96509 NZ_CP026854:68107-68388 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 10252.58 Da Isoelectric Point: 7.2057
>AT96509 WP_000079941.1 NZ_CP026854:67841-68110 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK
Download Length: 270 bp
>AT96509 NZ_CP026854:67841-68110 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | E9LLH3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A629TXC5 |