96496

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3193075..3193729 Replicon chromosome
Accession NZ_CP026853
Organism Escherichia coli strain MS7163

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag MS7163_RS16780 Protein ID WP_000244781.1
Coordinates 3193075..3193482 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag MS7163_RS16785 Protein ID WP_000354046.1
Coordinates 3193463..3193729 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS7163_RS16760 3189032..3190765 - 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -
MS7163_RS16765 3190771..3191481 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MS7163_RS16770 3191506..3192402 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
MS7163_RS16775 3192514..3193035 + 522 WP_001055874.1 flavodoxin FldB -
MS7163_RS16780 3193075..3193482 - 408 WP_000244781.1 protein YgfX Toxin
MS7163_RS16785 3193463..3193729 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
MS7163_RS16790 3193972..3194952 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
MS7163_RS16795 3195029..3195688 - 660 WP_000250274.1 hemolysin III family protein -
MS7163_RS16800 3195852..3196163 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
MS7163_RS16805 3196208..3197641 + 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T96496 WP_000244781.1 NZ_CP026853:c3193482-3193075 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T96496 NZ_CP026853:c3193482-3193075 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT96496 WP_000354046.1 NZ_CP026853:c3193729-3193463 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT96496 NZ_CP026853:c3193729-3193463 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References