Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 3654510..3655219 | Replicon | chromosome |
| Accession | NZ_CP026850 | ||
| Organism | Enterobacter cloacae complex sp. strain AR_0072 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A7D6YAQ1 |
| Locus tag | AM451_RS17825 | Protein ID | WP_071886833.1 |
| Coordinates | 3654851..3655219 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | AM451_RS17820 | Protein ID | WP_047051179.1 |
| Coordinates | 3654510..3654830 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM451_RS24550 (AM451_17780) | 3649744..3649974 | + | 231 | Protein_3374 | hypothetical protein | - |
| AM451_RS17780 (AM451_17785) | 3650070..3650904 | + | 835 | Protein_3375 | DUF945 domain-containing protein | - |
| AM451_RS17785 (AM451_17790) | 3651106..3651810 | + | 705 | WP_047051185.1 | WYL domain-containing protein | - |
| AM451_RS17790 (AM451_17795) | 3651807..3652421 | + | 615 | WP_047051184.1 | hypothetical protein | - |
| AM451_RS17795 (AM451_17800) | 3652510..3652920 | + | 411 | WP_047051183.1 | hypothetical protein | - |
| AM451_RS17800 (AM451_17805) | 3652997..3653233 | + | 237 | WP_047051182.1 | DUF905 domain-containing protein | - |
| AM451_RS17805 (AM451_17810) | 3653313..3653771 | + | 459 | WP_047051181.1 | antirestriction protein | - |
| AM451_RS17810 (AM451_17815) | 3653780..3654262 | + | 483 | WP_075211782.1 | DNA repair protein RadC | - |
| AM451_RS17815 (AM451_17820) | 3654271..3654492 | + | 222 | WP_016243789.1 | DUF987 domain-containing protein | - |
| AM451_RS17820 (AM451_17825) | 3654510..3654830 | + | 321 | WP_047051179.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AM451_RS17825 (AM451_17830) | 3654851..3655219 | + | 369 | WP_071886833.1 | TA system toxin CbtA family protein | Toxin |
| AM451_RS17830 (AM451_17835) | 3655565..3656311 | - | 747 | WP_047051178.1 | class I SAM-dependent methyltransferase | - |
| AM451_RS17835 (AM451_17840) | 3656322..3656579 | - | 258 | WP_003863178.1 | YjhX family toxin | - |
| AM451_RS17845 (AM451_17850) | 3656839..3657216 | - | 378 | Protein_3387 | EAL domain-containing protein | - |
| AM451_RS17850 (AM451_17855) | 3657266..3658234 | - | 969 | WP_022649395.1 | IS5-like element IS903B family transposase | - |
| AM451_RS17855 (AM451_17860) | 3658268..3659842 | - | 1575 | Protein_3389 | diguanylate cyclase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3640877..3677843 | 36966 | |
| - | flank | IS/Tn | - | - | 3657266..3658234 | 968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13738.90 Da Isoelectric Point: 8.1347
>T96469 WP_071886833.1 NZ_CP026850:3654851-3655219 [Enterobacter cloacae complex sp.]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ
Download Length: 369 bp
>T96469 NZ_CP026850:3654851-3655219 [Enterobacter cloacae complex sp.]
ATGAAAACTTTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCTCCAGTGGCTGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATCAAACCGTTATACAGGAACATATCG
ATGCGGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAAAAGTATGAGTTAGTACGTATCGATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGCAGTGA
ATGAAAACTTTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCTCCAGTGGCTGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATCAAACCGTTATACAGGAACATATCG
ATGCGGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAAAAGTATGAGTTAGTACGTATCGATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGCAGTGA
Antitoxin
Download Length: 107 a.a. Molecular weight: 11901.60 Da Isoelectric Point: 7.2633
>AT96469 WP_047051179.1 NZ_CP026850:3654510-3654830 [Enterobacter cloacae complex sp.]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS
Download Length: 321 bp
>AT96469 NZ_CP026850:3654510-3654830 [Enterobacter cloacae complex sp.]
ATGAGGAGTAACGCTACATGGGGACTGCAACGTGATATCACACCGCGTCTGGGAGCCCGTCTGGTGCAGGAGGGCAACCG
GCTCCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAATTCAGTGACGCCGAATGCCTGAAGTTGGATGTCGCATTCC
CGCATTTTATCAGTCTGATGGAATCAATGCTGACTACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTAC
CGCAACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGCTGCGGCTACTTATATATCGTTGTTTATCCCACTCAAAGCTA
A
ATGAGGAGTAACGCTACATGGGGACTGCAACGTGATATCACACCGCGTCTGGGAGCCCGTCTGGTGCAGGAGGGCAACCG
GCTCCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAATTCAGTGACGCCGAATGCCTGAAGTTGGATGTCGCATTCC
CGCATTTTATCAGTCTGATGGAATCAATGCTGACTACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTAC
CGCAACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGCTGCGGCTACTTATATATCGTTGTTTATCCCACTCAAAGCTA
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|