96463

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1765085..1765742 Replicon chromosome
Accession NZ_CP026850
Organism Enterobacter cloacae complex sp. strain AR_0072

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag AM451_RS08550 Protein ID WP_017382887.1
Coordinates 1765085..1765495 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AM451_RS08555 Protein ID WP_003863437.1
Coordinates 1765476..1765742 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM451_RS08530 (AM451_08530) 1761083..1762816 - 1734 WP_047050807.1 single-stranded-DNA-specific exonuclease RecJ -
AM451_RS08535 (AM451_08535) 1762822..1763535 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM451_RS08540 (AM451_08540) 1763564..1764460 - 897 WP_047050805.1 site-specific tyrosine recombinase XerD -
AM451_RS08545 (AM451_08545) 1764562..1765083 + 522 WP_015571793.1 flavodoxin FldB -
AM451_RS08550 (AM451_08550) 1765085..1765495 - 411 WP_017382887.1 protein YgfX Toxin
AM451_RS08555 (AM451_08555) 1765476..1765742 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AM451_RS08560 (AM451_08560) 1766037..1767017 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
AM451_RS08565 (AM451_08565) 1767129..1767788 - 660 WP_047050804.1 hemolysin III family protein -
AM451_RS08570 (AM451_08570) 1768055..1768786 + 732 WP_047050802.1 MurR/RpiR family transcriptional regulator -
AM451_RS08575 (AM451_08575) 1768903..1770336 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T96463 WP_017382887.1 NZ_CP026850:c1765495-1765085 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T96463 NZ_CP026850:c1765495-1765085 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT96463 WP_003863437.1 NZ_CP026850:c1765742-1765476 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT96463 NZ_CP026850:c1765742-1765476 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References