Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4118833..4119493 Replicon chromosome
Accession NZ_CP026846
Organism Shigella boydii strain 59-2708

Toxin (Protein)


Gene name cptA Uniprot ID A0A398Q8H4
Locus tag C1P57_RS20755 Protein ID WP_000244782.1
Coordinates 4118833..4119246 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P57_RS20760 Protein ID WP_000354046.1
Coordinates 4119227..4119493 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P57_RS20735 (4114798) 4114798..4116530 - 1733 Protein_4001 single-stranded-DNA-specific exonuclease RecJ -
C1P57_RS20740 (4116536) 4116536..4117245 - 710 Protein_4002 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P57_RS20745 (4117270) 4117270..4118166 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C1P57_RS20750 (4118278) 4118278..4118799 + 522 WP_001055874.1 flavodoxin FldB -
C1P57_RS20755 (4118833) 4118833..4119246 - 414 WP_000244782.1 protein YgfX Toxin
C1P57_RS20760 (4119227) 4119227..4119493 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P57_RS20765 (4119736) 4119736..4120716 + 981 WP_000886099.1 tRNA-modifying protein YgfZ -
C1P57_RS20770 (4120912) 4120912..4121571 - 660 WP_000250274.1 hemolysin III family protein -
C1P57_RS20775 (4121735) 4121735..4122046 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
C1P57_RS20780 (4122091) 4122091..4123524 + 1434 WP_004993952.1 6-phospho-beta-glucosidase BglA -
C1P57_RS20785 (4123581) 4123581..4124324 - 744 WP_000951945.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T96449 WP_000244782.1 NZ_CP026846:c4119246-4118833 [Shigella boydii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

>T96449 NZ_CP026846:c4119246-4118833 [Shigella boydii]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATCAAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT96449 WP_000354046.1 NZ_CP026846:c4119493-4119227 [Shigella boydii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT96449 NZ_CP026846:c4119493-4119227 [Shigella boydii]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A398Q8H4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References