96445

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2706474..2707000 Replicon chromosome
Accession NZ_CP026846
Organism Shigella boydii strain 59-2708

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag C1P57_RS13660 Protein ID WP_000323025.1
Coordinates 2706713..2707000 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag C1P57_RS13655 Protein ID WP_000534858.1
Coordinates 2706474..2706713 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P57_RS13640 (2703832) 2703832..2705058 + 1227 Protein_2645 pitrilysin family protein -
C1P57_RS25310 (2706324) 2706324..2706449 - 126 Protein_2647 protein YdfV -
C1P57_RS13655 (2706474) 2706474..2706713 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
C1P57_RS13660 (2706713) 2706713..2707000 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
C1P57_RS13665 (2707072) 2707072..2707227 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
C1P57_RS13670 (2707445) 2707445..2707696 + 252 WP_000980987.1 protein Rem -
C1P57_RS13675 (2707763) 2707763..2708041 + 279 WP_024258459.1 hypothetical protein -
C1P57_RS13680 (2708043) 2708043..2709086 + 1044 WP_134795747.1 DUF968 domain-containing protein -
C1P57_RS13685 (2709099) 2709099..2709456 + 358 Protein_2654 RusA family crossover junction endodeoxyribonuclease -
C1P57_RS13690 (2709471) 2709471..2710292 + 822 WP_078167389.1 antitermination protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vgrG/tssI 2695181..2713730 18549
- inside IScluster/Tn - - 2682433..2712374 29941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T96445 WP_000323025.1 NZ_CP026846:2706713-2707000 [Shigella boydii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T96445 NZ_CP026846:2706713-2707000 [Shigella boydii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT96445 WP_000534858.1 NZ_CP026846:2706474-2706713 [Shigella boydii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT96445 NZ_CP026846:2706474-2706713 [Shigella boydii]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References