Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1007745..1008295 Replicon chromosome
Accession NZ_CP026846
Organism Shigella boydii strain 59-2708

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag C1P57_RS04910 Protein ID WP_001160972.1
Coordinates 1007981..1008295 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag C1P57_RS04905 Protein ID WP_000125567.1
Coordinates 1007745..1007978 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P57_RS04880 (1002894) 1002894..1003181 + 288 WP_000203729.1 ferredoxin-like protein FixX -
C1P57_RS04885 (1003240) 1003240..1004571 + 1332 WP_134795572.1 MFS transporter -
C1P57_RS04890 (1004682) 1004682..1005212 + 531 WP_000600743.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
C1P57_RS04895 (1005205) 1005205..1006989 + 1785 WP_119180890.1 glutathione-regulated potassium-efflux system protein KefC -
C1P57_RS04900 (1007180) 1007180..1007659 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
C1P57_RS04905 (1007745) 1007745..1007978 + 234 WP_000125567.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
C1P57_RS04910 (1007981) 1007981..1008295 + 315 WP_001160972.1 CcdB family protein Toxin
C1P57_RS04915 (1008292) 1008292..1009140 - 849 WP_000257196.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
C1P57_RS04920 (1009147) 1009147..1009524 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
C1P57_RS04925 (1009527) 1009527..1010348 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
C1P57_RS04930 (1010345) 1010345..1011334 - 990 WP_134795573.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
C1P57_RS04935 (1011334) 1011334..1012620 - 1287 WP_078166226.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11801.86 Da        Isoelectric Point: 9.0851

>T96429 WP_001160972.1 NZ_CP026846:1007981-1008295 [Shigella boydii]
MQFTVYRSRSRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASTHRMLIKGALDFMLDGI

Download         Length: 315 bp

>T96429 NZ_CP026846:1007981-1008295 [Shigella boydii]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCACGCACCGAATGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8544.55 Da        Isoelectric Point: 5.8147

>AT96429 WP_000125567.1 NZ_CP026846:1007745-1007978 [Shigella boydii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSEEYRSF

Download         Length: 234 bp

>AT96429 NZ_CP026846:1007745-1007978 [Shigella boydii]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGAGGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References