Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 794931..795526 Replicon chromosome
Accession NZ_CP026846
Organism Shigella boydii strain 59-2708

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag C1P57_RS03880 Protein ID WP_000239579.1
Coordinates 795176..795526 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag C1P57_RS03875 Protein ID WP_001223208.1
Coordinates 794931..795182 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P57_RS03865 (792941) 792941..793282 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
C1P57_RS03870 (793375) 793375..794720 + 1346 Protein_744 IS4-like element IS4 family transposase -
C1P57_RS03875 (794931) 794931..795182 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C1P57_RS03880 (795176) 795176..795526 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
C1P57_RS03885 (795606) 795606..796136 - 531 WP_000055072.1 inorganic diphosphatase -
C1P57_RS03890 (796446) 796446..797402 + 957 WP_000265939.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
C1P57_RS03895 (797543) 797543..799045 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
C1P57_RS03900 (799059) 799059..800081 + 1023 WP_004996065.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T96426 WP_000239579.1 NZ_CP026846:795176-795526 [Shigella boydii]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T96426 NZ_CP026846:795176-795526 [Shigella boydii]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT96426 WP_001223208.1 NZ_CP026846:794931-795182 [Shigella boydii]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT96426 NZ_CP026846:794931-795182 [Shigella boydii]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References