Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 168090..168615 Replicon plasmid unnamed
Accession NZ_CP026841
Organism Shigella dysenteriae strain ATCC 9753

Toxin (Protein)


Gene name ccdB Uniprot ID Q326Z8
Locus tag C1P67_RS26035 Protein ID WP_001159860.1
Coordinates 168090..168395 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q7BEK0
Locus tag C1P67_RS26040 Protein ID WP_000813626.1
Coordinates 168397..168615 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P67_RS26005 164134..164831 + 698 WP_094106546.1 IS1 family transposase -
C1P67_RS26010 164849..165331 - 483 Protein_200 type III secretion system effector protein kinase OspG -
C1P67_RS27560 165414..165583 - 170 Protein_201 type II toxin-antitoxin system toxin YacB -
C1P67_RS26020 165583..165852 - 270 WP_000079956.1 type II toxin-antitoxin system antitoxin YacA -
C1P67_RS26025 166060..167697 - 1638 WP_129593020.1 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -
C1P67_RS26030 167959..168066 - 108 WP_023592908.1 transposase domain-containing protein -
C1P67_RS26035 168090..168395 - 306 WP_001159860.1 type II toxin-antitoxin system toxin CcdB Toxin
C1P67_RS26040 168397..168615 - 219 WP_000813626.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
C1P67_RS26050 169208..169480 + 273 WP_000019158.1 hypothetical protein -
C1P67_RS26055 169575..170788 + 1214 WP_171764190.1 IS3 family transposase -
C1P67_RS26065 170852..171982 + 1131 WP_134807531.1 IS91 family transposase -
C1P67_RS26070 172177..173268 - 1092 Protein_210 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - spa40 / spa40 / spa29 / spa9 / spa24 / spa33 / spa32 / spa13 / spa47 / spa15 / mxiA / mxiC / mxiD / mxiE / mxiM / mxiL / mxiN / mxiK / mxiJ / mxiI / mxiH / mxiG / ipgF / ipgE / ipgD / ipgD / icsB / ipgA / ipgB1 / ipgC / ipaB / ipaC / ipaD / ipaA / ipaJ / ospC3 / ipaH7.8 / ospD3/senA / ospC1 / senB / ipaH1.4 / ospE2 / ospI / ipgB2 / ospD1 / ospF / ospD2 / ospD2 / ospC4 / ospB / icsP/sopA / nleE / ospC2 / ospG / ipaH9.8 / papC / icsA/virG / virA / virA 1..215925 215925
- inside IScluster/Tn - ospG / ipaH9.8 156870..198993 42123


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11736.59 Da        Isoelectric Point: 6.4674

>T96424 WP_001159860.1 NZ_CP026841:c168395-168090 [Shigella dysenteriae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T96424 NZ_CP026841:c168395-168090 [Shigella dysenteriae]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8333.36 Da        Isoelectric Point: 6.2838

>AT96424 WP_000813626.1 NZ_CP026841:c168615-168397 [Shigella dysenteriae]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT96424 NZ_CP026841:c168615-168397 [Shigella dysenteriae]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTN3

Antitoxin

Source ID Structure
AlphaFold DB Q7BEK0

References