Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3059661..3060279 Replicon chromosome
Accession NZ_CP026840
Organism Shigella dysenteriae strain ATCC 9753

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C1P67_RS15780 Protein ID WP_001291435.1
Coordinates 3060061..3060279 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2S8DBD2
Locus tag C1P67_RS15775 Protein ID WP_000344810.1
Coordinates 3059661..3060035 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P67_RS15765 (3054750) 3054750..3055943 + 1194 WP_024258559.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C1P67_RS15770 (3055966) 3055966..3059115 + 3150 WP_001132446.1 efflux RND transporter permease AcrB -
C1P67_RS15775 (3059661) 3059661..3060035 + 375 WP_000344810.1 Hha toxicity modulator TomB Antitoxin
C1P67_RS15780 (3060061) 3060061..3060279 + 219 WP_001291435.1 HHA domain-containing protein Toxin
C1P67_RS15785 (3060451) 3060451..3061002 + 552 WP_000102569.1 maltose O-acetyltransferase -
C1P67_RS15790 (3061118) 3061118..3061588 + 471 WP_005025708.1 YlaC family protein -
C1P67_RS15795 (3061903) 3061903..3063131 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
C1P67_RS15800 (3063142) 3063142..3063507 + 366 Protein_3045 CSS-motif domain-containing protein -
C1P67_RS15805 (3063572) 3063572..3064728 + 1157 WP_094096479.1 IS3-like element IS600 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T96411 WP_001291435.1 NZ_CP026840:3060061-3060279 [Shigella dysenteriae]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T96411 NZ_CP026840:3060061-3060279 [Shigella dysenteriae]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14597.45 Da        Isoelectric Point: 4.6034

>AT96411 WP_000344810.1 NZ_CP026840:3059661-3060035 [Shigella dysenteriae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNYGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
EDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT96411 NZ_CP026840:3059661-3060035 [Shigella dysenteriae]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GAGGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8DBD2

References