Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1696122..1696753 Replicon chromosome
Accession NZ_CP026840
Organism Shigella dysenteriae strain ATCC 9753

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag C1P67_RS09000 Protein ID WP_001259385.1
Coordinates 1696478..1696753 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag C1P67_RS08995 Protein ID WP_000593554.1
Coordinates 1696122..1696481 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P67_RS08970 (1692254) 1692254..1693198 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
C1P67_RS08975 (1693195) 1693195..1694028 + 834 WP_001008964.1 nickel ABC transporter permease subunit NikC -
C1P67_RS08980 (1694028) 1694028..1694792 + 765 WP_001136222.1 nickel import ATP-binding protein NikD -
C1P67_RS08985 (1694789) 1694789..1695595 + 807 WP_000173706.1 nickel import ATP-binding protein NikE -
C1P67_RS08990 (1695601) 1695601..1696002 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
C1P67_RS08995 (1696122) 1696122..1696481 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C1P67_RS09000 (1696478) 1696478..1696753 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
C1P67_RS09005 (1696826) 1696826..1697950 - 1125 WP_001216258.1 ABC transporter permease -
C1P67_RS09010 (1697950) 1697950..1700685 - 2736 WP_134807439.1 ribosome-associated ATPase/putative transporter RbbA -
C1P67_RS09015 (1700682) 1700682..1701749 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T96408 WP_001259385.1 NZ_CP026840:c1696753-1696478 [Shigella dysenteriae]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T96408 NZ_CP026840:c1696753-1696478 [Shigella dysenteriae]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT96408 WP_000593554.1 NZ_CP026840:c1696481-1696122 [Shigella dysenteriae]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT96408 NZ_CP026840:c1696481-1696122 [Shigella dysenteriae]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References