Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1205375..1206029 Replicon chromosome
Accession NZ_CP026840
Organism Shigella dysenteriae strain ATCC 9753

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag C1P67_RS06365 Protein ID WP_000244777.1
Coordinates 1205375..1205782 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P67_RS06370 Protein ID WP_000354046.1
Coordinates 1205763..1206029 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P67_RS06345 (1201332) 1201332..1203065 - 1734 WP_000813209.1 single-stranded-DNA-specific exonuclease RecJ -
C1P67_RS06350 (1203071) 1203071..1203781 - 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P67_RS06355 (1203806) 1203806..1204702 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C1P67_RS06360 (1204814) 1204814..1205335 + 522 WP_001055874.1 flavodoxin FldB -
C1P67_RS06365 (1205375) 1205375..1205782 - 408 WP_000244777.1 protein YgfX Toxin
C1P67_RS06370 (1205763) 1205763..1206029 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P67_RS06375 (1206272) 1206272..1207252 + 981 WP_000886098.1 tRNA-modifying protein YgfZ -
C1P67_RS06380 (1207448) 1207448..1208107 - 660 WP_000250274.1 hemolysin III family protein -
C1P67_RS06385 (1208271) 1208271..1208582 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
C1P67_RS06390 (1208627) 1208627..1210060 + 1434 WP_004986559.1 6-phospho-beta-glucosidase BglA -
C1P67_RS06395 (1210117) 1210117..1210860 - 744 WP_000951947.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T96407 WP_000244777.1 NZ_CP026840:c1205782-1205375 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T96407 NZ_CP026840:c1205782-1205375 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGATTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT96407 WP_000354046.1 NZ_CP026840:c1206029-1205763 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT96407 NZ_CP026840:c1206029-1205763 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References