Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/COG2442-PIN |
| Location | 545029..545588 | Replicon | chromosome |
| Accession | NC_000911 | ||
| Organism | Synechocystis sp. PCC 6803 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | SGL_RS04395 | Protein ID | WP_010871694.1 |
| Coordinates | 545250..545588 (+) | Length | 113 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | SGL_RS04390 | Protein ID | WP_010871693.1 |
| Coordinates | 545029..545253 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SGL_RS04365 (slr1762) | 540062..540763 | + | 702 | WP_071822669.1 | HAD family hydrolase | - |
| SGL_RS04370 (slr1763) | 540863..542065 | + | 1203 | WP_010871689.1 | class I SAM-dependent methyltransferase | - |
| SGL_RS04375 (sll1642) | 542105..542596 | - | 492 | WP_010871690.1 | hypothetical protein | - |
| SGL_RS04380 (slr1764) | 542803..543342 | + | 540 | WP_010871691.1 | tellurium resistance TerZ family protein | - |
| SGL_RS04385 (sll1641) | 543468..544871 | - | 1404 | WP_010871692.1 | glutamate decarboxylase | - |
| SGL_RS04390 (ssr2962) | 545029..545253 | + | 225 | WP_010871693.1 | DUF433 domain-containing protein | Antitoxin |
| SGL_RS04395 (slr1767) | 545250..545588 | + | 339 | WP_010871694.1 | DUF5615 family PIN-like protein | Toxin |
| SGL_RS04400 (sll1640) | 545591..546556 | - | 966 | WP_010871695.1 | carbon-nitrogen hydrolase family protein | - |
| SGL_RS04405 (sll1639) | 546553..547365 | - | 813 | WP_014407074.1 | urease accessory protein UreD | - |
| SGL_RS04410 (sll1638) | 547425..547874 | - | 450 | WP_010871697.1 | photosystem II protein PsbQ | - |
| SGL_RS04415 (slr1768) | 548236..549132 | + | 897 | WP_010871698.1 | prohibitin family protein | - |
| SGL_RS04420 (sll1636) | 549129..549701 | - | 573 | WP_010871699.1 | gamma carbonic anhydrase family protein | - |
| SGL_RS04425 (slr1770) | 549994..550329 | + | 336 | WP_010871700.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 113 a.a. Molecular weight: 12464.32 Da Isoelectric Point: 4.2931
>T964 WP_010871694.1 NC_000911:545250-545588 [Synechocystis sp. PCC 6803]
MNIWVDAQLPPTLADWLSSNFDLEASALRDLGLRDARDIEIFDAARVANSVIMTKDSDFVDLVCRLGIPPQIIWLTCGNV
TNRNLRRILSSTLPQALEKLQAGEIIIEISNS
MNIWVDAQLPPTLADWLSSNFDLEASALRDLGLRDARDIEIFDAARVANSVIMTKDSDFVDLVCRLGIPPQIIWLTCGNV
TNRNLRRILSSTLPQALEKLQAGEIIIEISNS
Download Length: 339 bp
>T964 NC_000911:545250-545588 [Synechocystis sp. PCC 6803]
ATGAATATTTGGGTTGATGCTCAACTACCTCCAACATTGGCAGATTGGCTGTCGAGTAATTTTGATTTAGAGGCGTCAGC
TTTGAGGGATCTGGGATTACGGGATGCAAGAGACATTGAAATTTTTGATGCCGCACGAGTTGCCAACTCTGTAATCATGA
CAAAAGACAGCGACTTCGTTGATCTTGTATGTCGATTAGGAATACCACCTCAAATCATTTGGCTAACTTGCGGTAACGTT
ACGAATCGAAACTTACGTCGAATTCTCTCAAGTACTTTGCCACAGGCTCTGGAAAAACTGCAAGCAGGCGAAATTATCAT
AGAAATCAGCAACTCCTGA
ATGAATATTTGGGTTGATGCTCAACTACCTCCAACATTGGCAGATTGGCTGTCGAGTAATTTTGATTTAGAGGCGTCAGC
TTTGAGGGATCTGGGATTACGGGATGCAAGAGACATTGAAATTTTTGATGCCGCACGAGTTGCCAACTCTGTAATCATGA
CAAAAGACAGCGACTTCGTTGATCTTGTATGTCGATTAGGAATACCACCTCAAATCATTTGGCTAACTTGCGGTAACGTT
ACGAATCGAAACTTACGTCGAATTCTCTCAAGTACTTTGCCACAGGCTCTGGAAAAACTGCAAGCAGGCGAAATTATCAT
AGAAATCAGCAACTCCTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8232.51 Da Isoelectric Point: 4.6320
>AT964 WP_010871693.1 NC_000911:545029-545253 [Synechocystis sp. PCC 6803]
MNSLLSRITQTPGQCGGRPCIRGMRIRVSDILEMLAENVSTSEILEDFPDLEMADIQACLVFAARRTDFSRLTA
MNSLLSRITQTPGQCGGRPCIRGMRIRVSDILEMLAENVSTSEILEDFPDLEMADIQACLVFAARRTDFSRLTA
Download Length: 225 bp
>AT964 NC_000911:545029-545253 [Synechocystis sp. PCC 6803]
ATGAATAGCTTACTGTCTCGCATTACCCAAACCCCCGGTCAGTGTGGTGGTCGTCCTTGTATTCGAGGGATGAGGATTCG
AGTGAGCGACATCCTAGAAATGTTAGCTGAGAATGTTAGCACCTCTGAGATTTTAGAGGACTTTCCAGACCTAGAAATGG
CCGATATTCAGGCTTGTCTAGTGTTTGCTGCACGGCGGACTGATTTTTCCCGGTTGACGGCATGA
ATGAATAGCTTACTGTCTCGCATTACCCAAACCCCCGGTCAGTGTGGTGGTCGTCCTTGTATTCGAGGGATGAGGATTCG
AGTGAGCGACATCCTAGAAATGTTAGCTGAGAATGTTAGCACCTCTGAGATTTTAGAGGACTTTCCAGACCTAGAAATGG
CCGATATTCAGGCTTGTCTAGTGTTTGCTGCACGGCGGACTGATTTTTCCCGGTTGACGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Degang Ning et al. (2013) Transcriptional and proteolytic regulation of the toxin-antitoxin locus vapBC10 (ssr2962/slr1767) on the chromosome of Synechocystis sp. PCC 6803. PloS One 8(11):e80716. [PubMed:24260461]