Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3480154..3480772 Replicon chromosome
Accession NZ_CP026839
Organism Shigella dysenteriae strain ATCC 9752

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C1P69_RS18600 Protein ID WP_001291435.1
Coordinates 3480154..3480372 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag C1P69_RS18605 Protein ID WP_134804005.1
Coordinates 3480398..3480772 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P69_RS18575 (3475272) 3475272..3476222 - 951 Protein_3454 autotransporter adhesin EhaB -
C1P69_RS18580 (3476293) 3476293..3477461 + 1169 WP_134803099.1 IS3-like element IS911 family transposase -
C1P69_RS18585 (3477471) 3477471..3478531 - 1061 Protein_3456 IS3-like element IS2 family transposase -
C1P69_RS18590 (3478845) 3478845..3479315 - 471 WP_134804004.1 YlaC family protein -
C1P69_RS18595 (3479431) 3479431..3479982 - 552 WP_000102569.1 maltose O-acetyltransferase -
C1P69_RS18600 (3480154) 3480154..3480372 - 219 WP_001291435.1 HHA domain-containing protein Toxin
C1P69_RS18605 (3480398) 3480398..3480772 - 375 WP_134804005.1 Hha toxicity modulator TomB Antitoxin
C1P69_RS18610 (3481318) 3481318..3484467 - 3150 WP_134804006.1 efflux RND transporter permease AcrB -
C1P69_RS18615 (3484490) 3484490..3485683 - 1194 WP_134804007.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T96397 WP_001291435.1 NZ_CP026839:c3480372-3480154 [Shigella dysenteriae]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T96397 NZ_CP026839:c3480372-3480154 [Shigella dysenteriae]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14683.50 Da        Isoelectric Point: 4.5934

>AT96397 WP_134804005.1 NZ_CP026839:c3480772-3480398 [Shigella dysenteriae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNYGWVNDPTWAINLQLNELIEHIATFALNYKIKYNEDNKLIEQNDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT96397 NZ_CP026839:c3480772-3480398 [Shigella dysenteriae]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTGGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGAACGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References