Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4421866..4422526 Replicon chromosome
Accession NZ_CP026836
Organism Shigella boydii strain ATCC 49812

Toxin (Protein)


Gene name cptA Uniprot ID A0A398Q8H4
Locus tag C1P56_RS22645 Protein ID WP_000244782.1
Coordinates 4422113..4422526 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P56_RS22640 Protein ID WP_000354046.1
Coordinates 4421866..4422132 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P56_RS22615 (4417034) 4417034..4417778 + 745 Protein_4405 SDR family oxidoreductase -
C1P56_RS22620 (4417835) 4417835..4419268 - 1434 WP_141095393.1 6-phospho-beta-glucosidase BglA -
C1P56_RS22625 (4419313) 4419313..4419624 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
C1P56_RS22630 (4419788) 4419788..4420447 + 660 WP_000250274.1 hemolysin III family protein -
C1P56_RS22635 (4420643) 4420643..4421623 - 981 WP_000886099.1 tRNA-modifying protein YgfZ -
C1P56_RS22640 (4421866) 4421866..4422132 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P56_RS22645 (4422113) 4422113..4422526 + 414 WP_000244782.1 protein YgfX Toxin
C1P56_RS22650 (4422560) 4422560..4423081 - 522 WP_001055877.1 flavodoxin FldB -
C1P56_RS22655 (4423193) 4423193..4424089 + 897 WP_119171937.1 site-specific tyrosine recombinase XerD -
C1P56_RS22660 (4424114) 4424114..4424824 + 711 WP_119171938.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P56_RS22665 (4424830) 4424830..4426563 + 1734 WP_000813168.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T96383 WP_000244782.1 NZ_CP026836:4422113-4422526 [Shigella boydii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

>T96383 NZ_CP026836:4422113-4422526 [Shigella boydii]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACTCCGTTATGGATGGTGTTACTTTCGTTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATCAAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT96383 WP_000354046.1 NZ_CP026836:4421866-4422132 [Shigella boydii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT96383 NZ_CP026836:4421866-4422132 [Shigella boydii]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A398Q8H4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References