Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2921487..2922082 Replicon chromosome
Accession NZ_CP026836
Organism Shigella boydii strain ATCC 49812

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag C1P56_RS15215 Protein ID WP_000239579.1
Coordinates 2921487..2921837 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag C1P56_RS15220 Protein ID WP_001223208.1
Coordinates 2921831..2922082 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P56_RS15195 (2916932) 2916932..2917954 - 1023 WP_001353963.1 ABC transporter permease -
C1P56_RS15200 (2917968) 2917968..2919470 - 1503 WP_119172020.1 sugar ABC transporter ATP-binding protein -
C1P56_RS15205 (2919611) 2919611..2920567 - 957 WP_000265938.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
C1P56_RS15210 (2920877) 2920877..2921407 + 531 WP_000055072.1 inorganic diphosphatase -
C1P56_RS15215 (2921487) 2921487..2921837 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
C1P56_RS15220 (2921831) 2921831..2922082 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C1P56_RS15225 (2922346) 2922346..2923690 + 1345 Protein_2979 IS4-like element IS4 family transposase -
C1P56_RS15230 (2923730) 2923730..2924071 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2922857..2923690 833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T96381 WP_000239579.1 NZ_CP026836:c2921837-2921487 [Shigella boydii]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T96381 NZ_CP026836:c2921837-2921487 [Shigella boydii]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT96381 WP_001223208.1 NZ_CP026836:c2922082-2921831 [Shigella boydii]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT96381 NZ_CP026836:c2922082-2921831 [Shigella boydii]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References