Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2325961..2326579 Replicon chromosome
Accession NZ_CP026836
Organism Shigella boydii strain ATCC 49812

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C1P56_RS12345 Protein ID WP_001291435.1
Coordinates 2326361..2326579 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag C1P56_RS12340 Protein ID WP_119171621.1
Coordinates 2325961..2326335 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P56_RS12330 (2321050) 2321050..2322243 + 1194 WP_134796460.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C1P56_RS12335 (2322266) 2322266..2325415 + 3150 WP_001132466.1 efflux RND transporter permease AcrB -
C1P56_RS12340 (2325961) 2325961..2326335 + 375 WP_119171621.1 Hha toxicity modulator TomB Antitoxin
C1P56_RS12345 (2326361) 2326361..2326579 + 219 WP_001291435.1 HHA domain-containing protein Toxin
C1P56_RS12350 (2326751) 2326751..2327302 + 552 WP_000102564.1 maltose O-acetyltransferase -
C1P56_RS12355 (2327418) 2327418..2327888 + 471 WP_000136192.1 YlaC family protein -
C1P56_RS12360 (2328052) 2328052..2329602 + 1551 WP_134796461.1 cyclic-guanylate-specific phosphodiesterase PdeB -
C1P56_RS12365 (2329644) 2329644..2329997 - 354 WP_000878140.1 DUF1428 domain-containing protein -
C1P56_RS28495 (2330529) 2330529..2330852 - 324 WP_241559939.1 hypothetical protein -
C1P56_RS12375 (2331053) 2331053..2331280 - 228 WP_000513895.1 DUF2188 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - acrA / acrB 2320262..2339188 18926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T96376 WP_001291435.1 NZ_CP026836:2326361-2326579 [Shigella boydii]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T96376 NZ_CP026836:2326361-2326579 [Shigella boydii]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14603.48 Da        Isoelectric Point: 4.7395

>AT96376 WP_119171621.1 NZ_CP026836:2325961-2326335 [Shigella boydii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHCWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT96376 NZ_CP026836:2325961-2326335 [Shigella boydii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATTGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References