Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1002213..1002851 Replicon chromosome
Accession NZ_CP026836
Organism Shigella boydii strain ATCC 49812

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag C1P56_RS05190 Protein ID WP_000813794.1
Coordinates 1002675..1002851 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C1P56_RS05185 Protein ID WP_001270286.1
Coordinates 1002213..1002629 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P56_RS05165 (997465) 997465..998410 - 946 Protein_1019 ABC transporter permease -
C1P56_RS05170 (998411) 998411..999375 - 965 Protein_1020 ABC transporter ATP-binding protein -
C1P56_RS05175 (999393) 999393..1000374 - 982 Protein_1021 ABC transporter substrate-binding protein -
C1P56_RS05180 (1000792) 1000792..1002134 - 1343 Protein_1022 PLP-dependent aminotransferase family protein -
C1P56_RS05185 (1002213) 1002213..1002629 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
C1P56_RS05190 (1002675) 1002675..1002851 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
C1P56_RS05195 (1003073) 1003073..1003303 + 231 WP_000494244.1 YncJ family protein -
C1P56_RS05200 (1003395) 1003395..1005356 - 1962 WP_119172305.1 23S rRNA 5-hydroxycytidine C2501 synthase -
C1P56_RS05205 (1005429) 1005429..1005965 - 537 WP_000429147.1 DNA-binding transcriptional regulator SutR -
C1P56_RS05210 (1006057) 1006057..1007229 + 1173 WP_235869953.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T96367 WP_000813794.1 NZ_CP026836:c1002851-1002675 [Shigella boydii]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T96367 NZ_CP026836:c1002851-1002675 [Shigella boydii]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT96367 WP_001270286.1 NZ_CP026836:c1002629-1002213 [Shigella boydii]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT96367 NZ_CP026836:c1002629-1002213 [Shigella boydii]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGAGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATAGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References