Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 471690..472525 Replicon chromosome
Accession NZ_CP026836
Organism Shigella boydii strain ATCC 49812

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag C1P56_RS02515 Protein ID WP_001391462.1
Coordinates 472148..472525 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag C1P56_RS02510 Protein ID WP_096885499.1
Coordinates 471690..472058 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P56_RS02465 (467648) 467648..468130 + 483 WP_024257266.1 hypothetical protein -
C1P56_RS02470 (468232) 468232..468450 + 219 WP_032338470.1 DUF905 family protein -
C1P56_RS02480 (468568) 468568..469386 + 819 WP_119172611.1 DUF932 domain-containing protein -
C1P56_RS02490 (469728) 469728..470201 + 474 WP_133299701.1 antirestriction protein -
C1P56_RS02495 (470217) 470217..470693 + 477 WP_133299702.1 RadC family protein -
C1P56_RS02500 (470756) 470756..470977 + 222 WP_119172612.1 DUF987 domain-containing protein -
C1P56_RS02505 (470996) 470996..471640 + 645 Protein_482 antitoxin of toxin-antitoxin stability system -
C1P56_RS02510 (471690) 471690..472058 + 369 WP_096885499.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C1P56_RS02515 (472148) 472148..472525 + 378 WP_001391462.1 TA system toxin CbtA family protein Toxin
C1P56_RS02520 (472522) 472522..473010 + 489 WP_119172394.1 DUF5983 family protein -
C1P56_RS02525 (473027) 473027..473224 + 198 WP_000839284.1 DUF957 domain-containing protein -
C1P56_RS02530 (473309) 473309..474151 + 843 WP_001340503.1 DUF4942 domain-containing protein -
C1P56_RS02540 (474622) 474622..475560 + 939 WP_000351333.1 glyoxylate/hydroxypyruvate reductase GhrA -
C1P56_RS02545 (475615) 475615..476352 + 738 WP_000283664.1 zinc-binding phosphatase -
C1P56_RS02550 (476376) 476376..476930 + 555 WP_001001910.1 molecular chaperone YcdY -
C1P56_RS02555 (477032) 477032..477523 + 492 WP_001300785.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgG / csgF / csgE / csgD / csgB / csgA / csgC 454512..494176 39664


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14133.09 Da        Isoelectric Point: 7.8045

>T96364 WP_001391462.1 NZ_CP026836:472148-472525 [Shigella boydii]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SPCTRSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T96364 NZ_CP026836:472148-472525 [Shigella boydii]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCTGGATTC
AGCCCCTGTACCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGTCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13731.55 Da        Isoelectric Point: 7.0265

>AT96364 WP_096885499.1 NZ_CP026836:471690-472058 [Shigella boydii]
VSDKLHETTHPDDNNNRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT96364 NZ_CP026836:471690-472058 [Shigella boydii]
GTGTCAGACAAGCTCCATGAGACAACGCATCCCGATGACAATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCAGACCGCGCCGGCATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References