Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 88855..89380 Replicon plasmid unnamed
Accession NZ_CP026835
Organism Shigella dysenteriae strain ATCC 49347

Toxin (Protein)


Gene name ccdB Uniprot ID Q326Z8
Locus tag C5B83_RS25205 Protein ID WP_001159860.1
Coordinates 88855..89160 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q7BEK0
Locus tag C5B83_RS25210 Protein ID WP_000813626.1
Coordinates 89162..89380 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B83_RS26320 84695..84847 + 153 Protein_109 hypothetical protein -
C5B83_RS25175 84899..85596 + 698 WP_094106546.1 IS1 family transposase -
C5B83_RS25180 85614..86096 - 483 Protein_111 type III secretion system effector protein kinase OspG -
C5B83_RS26325 86179..86348 - 170 Protein_112 type II toxin-antitoxin system toxin YacB -
C5B83_RS25190 86348..86617 - 270 WP_000079956.1 type II toxin-antitoxin system antitoxin YacA -
C5B83_RS25195 86825..88462 - 1638 WP_129593020.1 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -
C5B83_RS25200 88724..88831 - 108 WP_023592908.1 transposase domain-containing protein -
C5B83_RS25205 88855..89160 - 306 WP_001159860.1 type II toxin-antitoxin system toxin CcdB Toxin
C5B83_RS25210 89162..89380 - 219 WP_000813626.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
C5B83_RS25215 89624..90852 + 1229 Protein_118 IS3-like element IS2 family transposase -
C5B83_RS25225 91309..91581 + 273 WP_000019158.1 hypothetical protein -
C5B83_RS25230 91676..92889 + 1214 WP_167544920.1 IS3 family transposase -
C5B83_RS25240 92953..94083 + 1131 WP_050546159.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospI / ipgB2 / ospD1 / ospF / ospD2 / ospB / icsP/sopA / nleE / ospC2 / ospG / ipaH9.8 1..99066 99066
- inside IScluster/Tn - ospG / ipaH9.8 85303..98886 13583


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11736.59 Da        Isoelectric Point: 6.4674

>T96359 WP_001159860.1 NZ_CP026835:c89160-88855 [Shigella dysenteriae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T96359 NZ_CP026835:c89160-88855 [Shigella dysenteriae]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8333.36 Da        Isoelectric Point: 6.2838

>AT96359 WP_000813626.1 NZ_CP026835:c89380-89162 [Shigella dysenteriae]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT96359 NZ_CP026835:c89380-89162 [Shigella dysenteriae]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTN3

Antitoxin

Source ID Structure
AlphaFold DB Q7BEK0

References