Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 154097..154622 Replicon plasmid unnamed
Accession NZ_CP026833
Organism Shigella dysenteriae strain ATCC 49346

Toxin (Protein)


Gene name ccdB Uniprot ID Q326Z8
Locus tag C5B81_RS25335 Protein ID WP_001159860.1
Coordinates 154317..154622 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q7BEK0
Locus tag C5B81_RS25330 Protein ID WP_000813626.1
Coordinates 154097..154315 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B81_RS25300 149395..150525 - 1131 WP_050546159.1 IS91 family transposase -
C5B81_RS25315 151896..152168 - 273 WP_000019158.1 hypothetical protein -
C5B81_RS25330 154097..154315 + 219 WP_000813626.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
C5B81_RS25335 154317..154622 + 306 WP_001159860.1 type II toxin-antitoxin system toxin CcdB Toxin
C5B81_RS25340 154646..154753 + 108 WP_023592908.1 transposase domain-containing protein -
C5B81_RS25345 155015..156652 + 1638 WP_134801162.1 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -
C5B81_RS25350 156860..157129 + 270 WP_000079956.1 type II toxin-antitoxin system antitoxin YacA -
C5B81_RS27065 157129..157298 + 170 Protein_193 type II toxin-antitoxin system toxin YacB -
C5B81_RS25360 157381..157863 + 483 Protein_194 type III secretion system effector protein kinase OspG -
C5B81_RS25365 157881..158577 - 697 Protein_195 IS1 family transposase -
C5B81_RS27070 158629..158781 - 153 Protein_196 hypothetical protein -
C5B81_RS26400 158747..158899 + 153 WP_171763767.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospI / ospE2 / ipaH1.4 / senB / ospC1 / ospD3/senA / ipaH7.8 / ipaH4.5 / ipaH9.8 / ospC3 / ipaJ / ipaA / ipaA / ipaD / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / icsB / ipgD / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / spa40 / virA / virA / icsA/virG / icsA/virG / papC / ipaH9.8 / ospG / ospC2 / nleE / icsP/sopA / icsP/sopA / ospB / ospD2 / ospD2 / ospF / ospD1 / ipgB2 1..224419 224419
- inside IScluster/Tn - ipaH9.8 / ospG 122001..164504 42503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11736.59 Da        Isoelectric Point: 6.4674

>T96331 WP_001159860.1 NZ_CP026833:154317-154622 [Shigella dysenteriae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T96331 NZ_CP026833:154317-154622 [Shigella dysenteriae]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8333.36 Da        Isoelectric Point: 6.2838

>AT96331 WP_000813626.1 NZ_CP026833:154097-154315 [Shigella dysenteriae]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT96331 NZ_CP026833:154097-154315 [Shigella dysenteriae]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTN3

Antitoxin

Source ID Structure
AlphaFold DB Q7BEK0

References