Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4303571..4304202 Replicon chromosome
Accession NZ_CP026832
Organism Shigella dysenteriae strain ATCC 49346

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag C5B81_RS22690 Protein ID WP_001259385.1
Coordinates 4303927..4304202 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3P6LLN4
Locus tag C5B81_RS22685 Protein ID WP_000593559.1
Coordinates 4303571..4303930 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B81_RS22660 (4299703) 4299703..4300647 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
C5B81_RS22665 (4300644) 4300644..4301477 + 834 WP_001008964.1 nickel ABC transporter permease subunit NikC -
C5B81_RS22670 (4301477) 4301477..4302241 + 765 WP_001136222.1 nickel import ATP-binding protein NikD -
C5B81_RS22675 (4302238) 4302238..4303044 + 807 WP_000173710.1 nickel import ATP-binding protein NikE -
C5B81_RS22680 (4303050) 4303050..4303451 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
C5B81_RS22685 (4303571) 4303571..4303930 - 360 WP_000593559.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C5B81_RS22690 (4303927) 4303927..4304202 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
C5B81_RS22695 (4304275) 4304275..4305399 - 1125 WP_001216257.1 ABC transporter permease -
C5B81_RS22700 (4305399) 4305399..4308134 - 2736 WP_000149136.1 ribosome-associated ATPase/putative transporter RbbA -
C5B81_RS22705 (4308131) 4308131..4309198 - 1068 WP_000361465.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T96326 WP_001259385.1 NZ_CP026832:c4304202-4303927 [Shigella dysenteriae]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T96326 NZ_CP026832:c4304202-4303927 [Shigella dysenteriae]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13373.27 Da        Isoelectric Point: 4.8838

>AT96326 WP_000593559.1 NZ_CP026832:c4303930-4303571 [Shigella dysenteriae]
MIKLKTPNTMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT96326 NZ_CP026832:c4303930-4303571 [Shigella dysenteriae]
ATGATCAAACTGAAGACGCCAAACACTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A3P6LLN4

References